CA199和CA242在胰腺癌诊断中应用价值.docVIP

CA199和CA242在胰腺癌诊断中应用价值 　　摘要：目的 探讨用蛋白芯片法检测CA199和CA242在胰腺癌诊断中应用价值。方法 用蛋白芯片法测定测定血清CA199和CA242水平。分别测定胰腺癌的患者（病例组60例）、胰腺良性疾病患者（对照组60例）的CA199和CA242水平。结果 胰腺癌患者血清中肿瘤标志物CA199和CA242的水平明显高于对照组，组间比较，差异有统计学意义（P0.05），病例组CA199和CA242的敏感性和特异性高于对照组，差异有统计学意义（P0.05），Ⅰ期和Ⅱ期患者胰腺癌血清肿瘤标志物水平显著低于Ⅲ期，差异有统计学意义（P0.05）。结论 检测CA199和CA242有利于胰腺癌临床诊断，可作为诊断胰腺癌的一项筛选指标。 　　关键词：胰腺癌；蛋白芯片；CA199 　　Value of Detection of CA199 and CA242in Diagnosis of Pancreatic Carcinoma 　　LIN Ding-li 　　（Department of Hepatobiliary Pancreatic Endoscopic Minimally Invasive Surgery，The First Affiliated Hospital of Fujian Medical University，Fuzhong 350000，Fujian，China） 　　Abstract：Objective To investigate the value of detection of CA199 and CA242 by application of protein chip in diagnosis of pancreatic carcinoma.Methods CA199 and CA242 were determined and analyzed in 60 patients with pancreatic carcinoma，60 patients with non-pancreatic tumors.Results The serum levels of CA199 and CA242in patients with pancreatic cancer were significantly higher than those in the patients with pancreatic benign lesion（P0.05）.The sensitivity and specificity of CA199 and CA242 in case group was higher than control group，the difference has statistical significance（P0.05）.Phase I and II tumor marker for pancreatic carcinoma was lower than Phase III，the difference was significant（P0.05）.Conclusion The detection of CA199 and CA242 is helpful for clinical diagnosis of pancreatic cancer，and can be used as a screening index for the diagnosis of pancreatic carcinoma. 　　Key words：Pancreatic carcinoma；Protein chip；CA199 　　胰腺癌是一种临床表现隐匿、难以治愈的消化系统恶性肿瘤。在所有恶性肿瘤中生存率最低，各国统计5年生存率为0.4%～4.0%[1]。CA199是目前最有效的胰腺癌诊断标志，存在于正常组织细胞中，在患有胰腺、胆管恶性疾病患者中，体液中的CA199常处于较高水平[2]。CA242存于多器官恶性肿瘤中的糖蛋白，是近几年用于临床较新的胰腺癌和结肠癌的肿瘤标志物。本文通过对胰腺癌患者血清CA199和CA242检测结果与胰腺良性疾病患者进行对比研究，探讨CA199和CA242在胰腺癌诊断中的意义。 　　1 资料与方法 　　1.1一般资料 选择2013年1月～2014年6月门诊和住院患者经CT、内镜和（或）病理确诊胰腺癌60例，男38例，女22例，平均54.6岁，国际抗癌联盟（UICC）TNM分期[3]，I期有10例，，Ⅱ期有22例，Ⅲ期有28例；胰腺良性疾病组60例，慢性胰腺炎46例、胰腺囊肿14例，男35例，女25例，平均55.7岁；经医院伦理委员会批准，并获患者同意并签订