CerbB2ERPR在子宫内膜癌中表达及其临床意义.doc

CerbB2ERPR在子宫内膜癌中表达及其临床意义 　　[摘要] 目的：通过癌因子（C-erbB-2）和雌孕激素受体（ER、PR）表达水平的检测分析，探讨其表达水平与子宫内膜癌发生、发展的关系。方法：对30例正常内膜、30例不典型增生、76例子宫内膜癌手术标本常规进行病理检查，采用免疫组化法进行标记。结果：C-erbB-2在子宫内膜不典型增生中出现了过度表达，子宫内膜癌表达率为76.3%，且C-erbB-2的表达与子宫内膜癌的病理分级和病理类型有关（P＜0.01，P＜0.05）。ER、PR在正常内膜中高表达，在子宫内膜不典型增生及子宫内膜癌中表达率下降，且与分级和病理类型有关（P＜0.01，P＜0.05）。C-erbB-2的表达与ER呈负相关。结论：C-erbB-2基因在子宫内膜癌发生发展中具有重要意义，是评价子宫内膜癌预后的指标。 　　[关键词] C-erbB-2；ER；PR；子宫内膜癌；免疫组化 　　[中图分类号] R737 [文献标识码] A [文章编号]1673-7210（2007）06（c）-019-02 　　 　　Expression and clinical significance of C-erbB-2、ER、PR in endometrial cancer 　　SUN Nai-ying，SUN Ming-qiang，DAI Shu-ling，ZHOU Li 　　（Department ofPathology,Weifang Women and Children Hospital,Weifang 261011,China） 　　[Abstract]Objective：By analyzing the expression levels of cancer factor（C-erbB-2）,estrogen and progesterone receptors,to explore their expressions and the relations of happened and development of endometrial cancer,as a prognostic indicator .Metheds：30 cases of normal endometrium,30 cases of atypical hyperplasia,76 cases of endometrial cancer specimens were examined by routine pathological and marked through immunohistochemical technique.Results：C-erbB-2 was overexpression in endometrial hyperplasia,the positive of rate was 76.3% in endometrial carcinoma. C-erbB-2 expression was related with the pathological grade and types（P＜0.01）.Both ER and PR were overexpression in normal endometrium,their positibe of rate were decline in endometrial hyperplasisa and endometrial carcinoma.Their expressions were related with the pathological grade and types（P＜0.01）.C-erbB-2 expressin was negatively correlated with ER.Conclusion：C-erbB-2 gene in the development of endometrial cancer is of great significance,We can evaluate endometrial cancer as a prognostic indicator. 　　[Key words]C-erbB-2;ER;PR;Endometrial carcinoma;Immunohistochemistry 　　 　　子宫内膜癌被认为是激素依赖型肿瘤[1]。与正常内膜一样多数子宫内膜癌含有雌激素受体（ER）和孕激素受体（PR）。受体含量与许多临床病理特征有关，是预测预后和指导治疗的重要因素之一[2]。C-erbB-2的过表达发现于多种肿瘤，与肿瘤的分化程度密切相关[3]。本文用免疫组织化学方法对子宫内膜癌中C-erbB-2基因与