CerbB2和P53在胃癌中表达及其临床意义.doc

CerbB2和P53在胃癌中表达及其临床意义 　　[摘要] 目的 探讨CerbB-2、P53基因在胃癌中的表达情况，及其与胃癌预后的关系。方法 采用免疫组化S-P法测定胃癌石蜡切片组织中CerbB-2、P53蛋白的表达情况。结果 CerbB-2、P53在胃癌组织中的阳性表达率分别为75.6%、86.0%，且与胃癌分化程度成正相关(P0.05）； P53单独表达及CerbB-2、P53同时表达与胃癌淋巴结转移有显著性差异（P0.05）。结论 CerbB-2、P53可以作为判断胃癌预后的指标，并为靶向治疗提供了理论依据。 　　[关键词] 胃癌； CerbB-2；P53； 免疫组织化学； 靶向治疗 　　[中图分类号] R735.2[文献标识码] B[文章编号] 1005-0515（2011）-03-014-02 　　 　　Expression and clinical significance of CerbB-2 and P53 protein in human gastric carcinoma 　　DENG Min1,TANG Ping2, ZHANG Fan3. 　　(1Department of Pathology, Fuyang Peoples Hospital, Fuyang 311400, Zhejiang, China；2.Hexian hospital traditional Chinese medicine,Hexian 238200,Anhui,China 3Yijishan Hospital of Wannan Medical College, wuhu 241001, Anhui, China) 　　[Abstract] Objective To investigate the correlation between CerbB-2, P53 protein expression and prognosis of gastric carcinoma. Methods Adopting immunohistochemistry technique(S-P) to detect the expression of CerbB-2 and P53 in human gastric carcinoma. Results The positive rate of CerbB-2 and P53 protein overexpression in human gastric carcinoma were 75.6% and 86.0%, respectively. CerbB-2 and p53 protein overexpression were associated with tumor differentiation, but CerbB-2 protein overexpression was not associated with lymph node metastasis (P 0.05)；P53 protein, CerbB-2、P53 protein simultaneously overexpression were showed statistic significance with lymph node metastasis（P0.05）. Conclusions DetectionCerbB-2 and P53 protein expression may be usedtoassess the m alignant biological behavior and prognosis of gastric cancer. Gastric cancer patients exhibiting CerbB-2 protein overexpression might constitute potentialcandidatesfor newadjuvanttherapies that involve the use of humanized monoclonal anti-bodies. 　　[Keywords]Gastric cancer; CerbB-2; P53; Immunohistochemistry; Targeted therapy 　　 　　胃癌是世界上导致死亡的第二大肿瘤，通常大部分患者在确诊时已发展到了晚期，此时化疗效果并不明显。在胃癌中发现表皮生长因子受体2（CerbB-2）基因的高表达为我们治疗胃癌提供了一个靶向治疗的靶点，但有关该基因与胃癌关系的研究较少。国内关于CerbB-2与胃癌分化程度、淋巴结转移的关系研究结果报道不一[1-3]，CerbB