p53Ki67基因表达与膀胱癌相关性回顾性研究.docVIP

p53Ki67基因表达与膀胱癌相关性回顾性研究 　　[摘要] 目的:探讨p53、Ki-67基因表达与膀胱癌(BTCC)病理学分级、临床分期及膀胱癌复发的关系。方法:回顾性分析149例膀胱癌患者的临床病历资料和p53、Ki-67(≥20为阳性)表达值。结果:Ⅰ、Ⅱ级阳性表达率p53为58.8%,Ki-67为64.7%,Ⅲ级阳性表达率p53为80.0%,Ki-67为90.0%;两组p53、Ki-67基因表达率差异有统计学意义(P0.05)。浅表型BTCC(Ta～T1)表达率p53为50.0%,Ki-67为52.4%;浸润型BTCC(T2～T4)表达率p53为80.0%,Ki-67为92.3%。浸润型BTCC的p53、Ki-67基因表达均高于浅表型BTCC(P0.05)。在高分级、高分期BTCC组p53、Ki-67联合表达率(73.3%、73.8%)高于低分级、低分期BTCC组(44.5%、32.1%),P0.005。p53、Ki-67共同表达阳性者复发率为37.5%,单一阳性或阴性表达者复发率15.6%,两组复发率有显著性差异(χ?2=7.46,P0.01)。结论:p53、Ki-67基因表达与膀胱癌的临床分期、病理学分级相关,提示p53、Ki-67蛋白过度表达的膀胱癌高度恶性和预后不良;p53、Ki-67基因共同表达阳性组复发率较单一阳性或阴性组复发率高,提示p53和Ki-67基因联合表达与膀胱癌复发可能有相关性。?[关键词] 膀胱癌; p53; Ki-67; 基因表达? 　　[中图分类号] R737.14; Q786[文献标识码] A[文章编号] 1671-7562(2010)01-0032-04? 　　doi:10.3969/j.issn.1671-7562.2010.01.009?? 　　 　　Retrospective research for the correlation between p53, Ki-67 gene ? 　　expression and bladder carcinoma?? 　　YANG Li-xin?1, ZHANG Hai-feng?2, BAI Shu-fen?1 　　(1. Department of Surgery, the Second Hospital, Southeast University, Nanjing 210003, China; 2. Department of ? 　　Urology, the First Hospital, Jilin University, Changchun 130021, China)?? 　　[Abstract] Objective: To explore the relationship between the expression of p53 and Ki-67 with pathologic grades, clinical stages and recurrence of bladder carcinoma and to find out the basic of clinical diagnosis and treatment of bladder carcinoma. Methods: We retrospectively analyzed clinical information and p53(20% was positive), Ki-67 expression(20% was positive) of 149 patients with bladder carcinoma. Results: Positive expressions in Ⅰ?Ⅱ grade tumors were 58.8%(p53) and 64.7%(Ki-67) respectively. The positive expressions in Ⅲ grade tumor were 80.0%(p53) and 90.0%(Ki-67). The differences of the gene expression in two groups had statistical significance(P0.05). The expression rates in Ta-T1(superficial type) tumors were 50.0%(p53) and 52.4%(Ki-67). The expression rates in T2-T4(invasive type) tumors were 80.0%(p53) and 92.3%(Ki-67). The expressions of p53 and Ki-67