不同剂量叶酸联合降压药治疗H型高血压临床对比分析.docVIP

不同剂量叶酸联合降压药治疗H型高血压的临床对比分析 　　[摘要] 目的 对比分析不同剂量叶酸联合降压药治疗H型高血压的临床疗效。方法 整群选取该院2014年7月―2016年1月收治的156例H型高血压患者，随机分为3组，各52例。A组口服小剂量（0.8 mg）叶酸片+马来酸依那普利片，B组口服大剂量叶酸片（5 mg）+马来酸依那普利片，C组仅予马来酸依那普利片治疗。比较3组治疗效果。结果 A组、B组治疗后收缩压、舒张压、Hcy水平分别为（119.86±8.56）mmHg、（73.41±7.89）mmHg、（12.25±5.96）μmol/L和（120.85±9.04）mmHg、（75.02±9.96）mmHg、（11.89±6.14）μmol/L，均明显低于C组的（134.33±11.25）mmHg、（84.27±6.50）mmHg、（16.77±4.92）μmol/L，（P0.05）。结论 叶酸联合降压药治疗H型高血压能明显改善血压与Hcy水平，小剂量用药即可达到较好效果。期待大规模临床实验进一步研究探讨。 　　[关键词] 叶酸 ；依那普利； H型高血压； 同型半胱氨酸 　　[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-0742（2016）08（b）-0117-03 　　[Abstract] Objective To contrastanalysis of different doses of folic acid with antihypertensive drug therapy H the clinical curative effect of high blood pressure.Methods Group selection 156 patients with H hypertension patients in our hospital from July 2014 to January 2016 were selected as the research objects and were randomly divided into three groups， 52 cases in each group.Patients in group A were taken a small dose of folic acid（0.8 mg）+enalapril maleatetablets orally， and Patients in group B a large dose of folic acid（5 mg） + enalapril maleatetablets orally，while patients in group C were only given enalapril maleatetablets. The clinical effects among the three groups were compared. Results After treatment， systolic pressure， diastolic pressure and the level of Hcyobviously of patients in group A，group B is respectively （119.86±8.56） mmHg， （73.41±7.89） mmHg、（12.25±5.96） μmol/L and （120.85±9.04） mmHg、（75.02±9.96） mmHg、（11.89±6.14）μmol/L， which decreased significantly compared with （134.33±11.25）mmHg、（84.27±6.50）mmHg、（16.77±4.92） μmol/L in group C（P0.05）.Conclusion Folic acid in combination with the antihypertensive drug treatment H high blood pressure can improve blood pressure and the level of Hcyobviously， and small dose of medication can achieve good curative effect.Looking forward to large-scale clinical trials to further research. 　　[Key words] Folicacid； Enalapril； H hypertension； Homocysteine 　　目前中