三维适形放疗联合紫杉醇单药每周化疗治疗老年非小细胞肺癌疗效观察.docVIP

三维适形放疗联合紫杉醇单药每周化疗治疗老年非小细胞肺癌的疗效观察 　　[摘要] 目的 探讨三维适形放疗（3D-CRT）联合紫杉醇单药每周化疗治疗老年非小细胞肺癌（NSCLC）的临床疗效。方法 选取2014年1月～2016年1月我院收治的68例NSCLC老年患者作为研究对象，随机分为观察组和对照组，观察组行3D-CRT联合紫杉醇每周化疗，对照组行单纯3D-CRT治疗，观察两组治疗的不良反应及治疗结束2周后的疗效。 结果 观察组治疗有效率85.3%显著高于对照组的52.9%，差异有统计学意义（P0.05），但观察组患者的毒副反应发生率高于对照组，差异有统计学意义（P0.05）。 结论 3D-CRT联合紫杉醇单药每周化疗治疗老年NSCLC具有较好的疗效，虽然毒副反应也有所增加，但尚在患者耐受范围之内。 　　[关键词] 三维适形放疗；紫杉醇；非小细胞肺癌；老年 　　[中图分类号] R734.2 [文献标识码] B [文章编号] 1673-9701（2016）24-0075-03 　　[Abstract] Objective To explore the clinical curative effects of three-dimensional conformal radiotherapy（3D-CRT） combined with paclitaxel alone in the weekly chemotherapy of elderly non-small cell lung cancer（NSCLC）. Methods 68 elderly patients with NSCLC who were admitted to our hospital from January 2014 to January 2016 were selected as research subjects. They were randomly assigned to the observation group and the control group. The observation group was given 3D-CRT combined with paclitaxel for weekly chemotherapy， and the control group was given CD-CRT alone for the treatment. Adverse reactions of the treatment and the curative effects 2 weeks after the end of treatment were observed in the two groups. Results The effective rate in the observation group was 85.3%， significantly higher than that of 52.9% in the control group（P0.05）， but the incidence rate of toxic and adverse reactions in the patients in the experiment group was higher than that in the control group（P0.05）. Conclusion 3D-CRT combined with paclitaxel alone in the weekly chemotherapy of elderly NSCLC has favorable curative effects. Although the toxic and adverse reactions are more common， it is still within patients tolerance range. 　　[Key words] Three-dimensional conformal radiotherapy； Paclitaxel； Non-small cell lung cancer； Elderly 　　肺癌是发病率、死亡率都极高的恶性肿瘤之一，而非小细胞肺癌（NSCLC）则是临床上最常见的肺癌，占全部肺癌的80%[1]。由于NSCLC早期无特征性表现，多数患者确诊时病情已发展至中晚期，常常失去手术治疗的机会，因此通常采用放化疗进行治疗。而随着我国人口老龄化的日益严重，老年NSCLC的患者不断增多，人们也开始更加关注和重视老年NSCLC患者的综合治疗[2]。现阶段在对晚期NSCLC患者进行治疗时，以铂类为主的联合化疗是公认的标准化疗方案；