三维适形放疗辅助替吉奥治疗老年中晚期食管癌可行性及安全性研究.docVIP

三维适形放疗辅助替吉奥治疗老年中晚期食管癌的可行性及安全性研究 　　[摘要] 目的 探讨三维适形放疗辅助替吉奥治疗老年患者中晚期食管癌的可行性及安全性。 方法 共选取93例患者，观察组45例患者采用三维适形放疗辅助替吉奥治疗，对照组48例患者仅采用三维适形放疗。放疗剂量为95%PTV 60～63 Gy/32～35次；服药时机为患者首次接受放疗开始，早饭及晚饭后各服1次，28 d为1个疗程，共服用2个疗程。 结果 93例患者均完成治疗期间的全部治疗过程，患者在短期内的治疗效果较明显，其中观察组的有效率为93.3%，高于对照组的81.2%（P0.05）。观察组1、3年的生存率为71.1%、46.7%，高于对照组的64.6%、39.6%（P0.05）。 结论 三维适形放疗辅助替吉奥治疗老年患者中晚期食管癌的短期效果及对延长患者的生存时间均有较好效果，适用于临床中晚期食管癌的治疗。 　　[关键词] 三维适形放疗；替吉奥；中晚期食管癌 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-4721（2014）09（b）-0045-03 　　Feasibility and safety study on three-dimensional conformal radiotherapy assisted tegafur gimeracil oteracil potassium in the treatment of middle and advanced esophageal cancer in elderly patients 　　WANG Hong-yun SHU Yun WU Yan-ling TAO Li-ming HU Xian-chun 　　The First Department of Tumor，the Third People′s Hospital of Jiujiang City in Jiangxi Province，Jiujiang 332000，China 　　[Abstract] Objective To explore the feasibility and safety of three-dimensional conformal radiotherapy assisted tegafur gimeracil oteracil potassium in the treatment of middle and advanced esophageal cancer in elderly patients. Methods A total of 93 patients were selected，among them，45 patients of the observation group received three-dimensional conformal radiotherapy assisted tegafur gimeracil oteracil potassium treatment and 48 patients of the control group received only three-dimensional conformal radiotherapy.The radiotherapy dose was 95% PTV 60-63 Gy/32-35 times；Medication time started from the patients′ first time of receiving radiotherapy and the patients took medicine once at breakfast and dinner respectively，and 1 treatment course lasted for 28 days and the medication lasted for 2 treatment courses. Results 93 patients completed the whole treatment process of the treatment period and the patients′ short-term treatment effects were obvious，the effective rate of the observation group （93.3%） was higher than of the control group （78.6%） （P0.05）.The 1-year and 3-year survival rate of the observation group （