三阶段光动力疗法治疗男性尖锐湿疣临床研究.docVIP

三阶段光动力疗法治疗男性尖锐湿疣的临床研究 　　[摘要] 目的 研究三阶段光动力疗法对男性尖锐湿疣治疗效果及复发率的影响。 方法 选择2012年4月～2014年4月河北工程大学附属医院男性尖锐湿疣患者180例，采用随机数字表法分为3组，每组60例。A组单纯采用二氧化碳激光治疗；B组采用二氧化碳激光7～10 d后进行光动力治疗，每周1次，连续治疗3次；C组采用二氧化碳激光联合光动力治疗结束10 d后外用咪喹莫特乳膏，每周3次，连用8周。三组治疗结束后每2～4周随访疗效及复发情况，并进行组间比较。 结果 治疗24周后，A组治愈33例，治愈率为55.0%，复发27例，复发率达45.0%；B组治愈52例，治愈率为86.7%，复发8例，复发率为13.3%；C组治愈58例，治愈率为96.7%，复发2例，复发率为3.3%；三组治愈率及复发率比较，差异均有统计学意义（P 0.05）；C组的治愈率高于A组和B组，复发率低于A组和B组。 结论 三阶段光动力治疗可降低男性锐湿疣复发率，提高治愈率，值得临床推广。 　　[关键词] 三阶段光动力疗法；尖锐湿疣；复发 　　[中图分类号] R752.53 [文献标识码] A [文章编号] 1673-7210（2016）05（a）-0012-04 　　[Abstract] Objective To observe the effect of three stage photodynamic therapy on therapeutic effect and recurrence rate of male patients with condylome acuminate （CA）. Methods 180 male patients with CA in Affiliated Hospital of Hebei Engineering University from April 2012 to April 2014 were divided into three groups by random number table， each group had 60 cases. Group A was given the treatment of CO2 laser separately. Group B was given photodynamics therapy after 7-10 days CO2 laser therapy， once a week for 3 times. Group C was given CO2 laser combined with photodynamics therapy for 10 days， then external use of Imiquimod Cream， 3 times a week， for 8 weeks. The three groups were followed up every 2-4 weeks after treatment， the efficacy and recurrence were observed and compared. Results After 24 weeks of treatment， in group A there were 33 cases of cure， the cure rate was 55.0%； 27 cases of recurrence， the recurrence rate was 45.0%. In group B there were 52 cases of cure， the cure rate was 86.7%； 8 cases of recurrence， the recurrence rate was 13.3%. In group C there were 58 cases of cure， the cure rate was 96.7%； 2 cases of recurrence， the recurrence rate was 3.3%. There were statistically significant in cure rate and recurrence rate among the three groups （P 0.05）. The cure rate in group C was significantly higher than that in group A and group B， the recurrence rate was lower than those two groups. Conclusion Three stage p