不同剂量米非司酮治疗108例更年期功血临床观察.docVIP

不同剂量米非司酮治疗108例更年期功血的临床观察 　　【摘要】 目的：分析不同剂量米非司酮治疗更年期功血的临床疗效。方法：将2011年10月-2013年10月笔者所在医院收治的108例更年期功血患者作为研究对象，按照随机数字表法分为试验组和对照组，各54例。试验组口服低剂量米非司酮6.25 mg，对照组口服较大剂量米非司酮12.5 mg，1次/d，疗程3个月。对比两组有效率、复发率、闭经率和不良反应发生率。结果：治疗后两组患者均明显好转，有效率、复发率和闭经率比较差异无统计学意义（P0.05）；试验组不良反应发生率为5.56%，对照组为25.93%，两组比较差异有统计学意义（P0.05）。结论：在治疗更年期功血时，米非司酮的疗效显著；与较大剂量治疗相比，低剂量治疗的不良反应发生率低，安全性高，经济有效，推荐在临床治疗中使用。 　　【关键词】 米非司酮； 低剂量； 更年期功血 　　中图分类号 R711.52 文献标识码 B 文章编号 1674-6805（2015）4-0025-02 　　Clinical Observation of Different Doses of Mifepristone in the Treatment of 108 Cases of Perimenopausal Functional Menorrhagia/ZHANG Jun-mei.//Chinese and Foreign Medical Research，2015，13（4）：25-26 　　【Abstract】 Objective：To analyze and compare the clinical effects of different doses of Mifepristone in the treatment of perimenopausal functional menorrhagia.Method：108 patients with perimenopausal functional menorrhagia，who received the treatment from Oct 2011 to Oct 2013 in our hospital were selected，based on different doses，they were divided into the experimental group and the control group，54 cases in each group.The experimental group was given low dose of Mifepristone（6.25 mg），and the control group was given larger dose of Mifepristone（12.5 mg），once a day for 3 months.The effective rate，recurrence rate，amenorrhea rate and adverse effects rate of two groups were compared.Result：Two groups had remarkable improvements after taking mifepristone.The effective rate，recurrence rate and amenorrhea rate of two groups，there was no statistical significance（P0.05）.The adverse effects rate of the experimental group was 5.56%，and the control group was 25.93%，the difference was statistically significant（P0.05）.Conclusion：Mifepristone has a significant effect in the treatment perimenopausal functional menorrhagia.Comparing with larger dose，low doses of Mifipristone has a lower adverse effects rate，higher safety and better economical efficiency.Recommend the use of low dose of mifepristone in the clinical treatment. 　　【Key words】 Mifep