新生儿脐血IgE水平在不同过敏症状组中的分布-安徽医药.DOCVIP

新生儿脐血IgE水平对幼儿不同过敏性疾病预测的研究 王节1，纪东1，桂晓钟1 摘要：【目的】研究新生儿的脐血IgE水平在幼儿不同过敏性疾病预测中的作用。【方法】收集新生儿的脐血标本，测定脐血IgE结果，随访至3-4岁，完善过敏相关症状的问卷调查。将过敏相关症状分成四组：无症状组、皮肤症状组、呼吸症状组和多症状组，观察脐血IgE水平在不同过敏症状组中的分布有无差别。【结果】过敏相关问卷调查结果如下：无症状组46例、皮肤症状组30例、呼吸症状组50例和多症状组79例。脐血IgE水平在不同过敏症状组中的分布经秩和检验，差异无统计学意义。【结论】新生儿脐血 IgE 水平可作为致敏指标，预测过敏性疾病的发生，但不能预测过敏相关的具体皮肤、呼吸等症状的发生。 关键词：新生儿；脐血IgE；幼儿；过敏性疾病 The significance of umbilical cord blood IgE levels in the prediction of different allergic diseases in infants Wang Jie, Ji Dong, Gui Xiaozhong Abstract: 【Objective】To study the significance of umbilical cord blood IgE levels in the prediction of different allergic diseases in infants. 【Methods】Newborn cord blood specimens were collected, and the cord blood IgE levels were measured. All the patients were followed up to 3-4 years old, then allergy-related symptoms were investigated. Allergy-related symptoms were divided into four groups: asymptomatic group, skin symptom group, respiratory symptom group and multi-symptom group. The distribution of IgE in umbilical cord blood in different allergic symptoms group was observed. 【Results】 Allergy related questionnaire survey results were as follows: 46 cases of ________________________ 通信作者：纪东，女，副主任医师，硕士生导师，研究方向变态反应，E-mail：jidong201230@163.com asymptomatic group, 30 cases of skin symptom group, 50 cases of respiratory symptom group and 79 cases of multiple symptom group. Cord blood IgE levels in the distribution of different symptoms in the rank sum test, the difference was not statistically significant.【Conclusion]】Newborn cord blood IgE levels can be used as sensitization indicators to predict the occurrence of allergic diseases, but can not predict allergy-related specific skin, respiratory and other symptoms. Key words: neonates; umbilical cord blood IgE; infant; allergic diseases 在过去几十年中，流行病学资料显示过敏性疾病的发病率显著增加。儿童期过敏性疾病的发病率也逐渐上升，儿童期主要过敏性症状包括皮肤皮疹、鼻部症状和吼喘[1]，其发病率高、病程长、病情重，从而严重困扰幼儿的生长发育，迫切需要早期干预和治疗。过敏倾向在妊娠期间即已开始，故过敏性疾病常常在生命的早期阶段被诊断[2]。自20世纪70年代以来，脐带血IgE水平在预测过敏性疾病中的作用已被广泛讨论，并且