不稳定型心绞痛患者血清sCD40L和sFas水平及相关分析.docVIP

不稳定型心绞痛患者血清sCD40L和sFas的水平及相关分析 　　[摘要] 目的：探讨不稳定型心绞痛（UAP）患者血清可溶性CD40L（sCD40L）水平的变化和可溶性Fas（sFas）水平的相关性。方法：应用酶联免疫吸附法对60例不稳定型心绞痛患者进行了血清sCD40L和血清sFas检测并与40例正常健康人做比较。结果：危险分层为Ⅱ、Ⅲ级的不稳定型心绞痛患者血清sCD40L与sFas水平非常显著地高于正常对照组（P0.01）；组间比较，危险分级Ⅱ、Ⅲ级UAP患者血清sCD40L与sFas水平明显高于危险分级Ⅰ级组；不稳定型心绞痛患者血清sCD40L水平与sFas水平呈明显正相关（r=0.573，P0.01）。结论：高水平的血清sCD40L和sFas与不稳定型心绞痛有关，可能通过细胞凋亡和炎症反应途径参与冠状动脉粥样硬化斑块的发生发展。 　　[关键词] 不稳定型心绞痛；血清可溶性CD40L(sCD40L) ；可溶性Fas（sFas） 　　[中图分类号] R541.4[文献标识码]Ａ [文章编号]1673-7210（2011）02（c）-055-02 　　Study on the relationship between serum sCD40L and soluble Fas levels in patients with unstable angina pectoris 　　LI Jinliang1, YANG Zhaoying2＃, WANG Weimin1, KONG Jian3 　　(1.Department of Cardiology, Heilongjiang Province Hospital, Harbin 150036, China; 2.Department of Gerontal Cardiology， Heilongjiang Province Hospital, Harbin 150036, China;3.Department of Cadre Ward, The First Hospital of Jilin University，Changchun 130021, China) 　　[Abstract] Objective: To study the relationship between changes of serum sCD40L and soluble Fas(sFas) levels in patients with unstable angina pectoris. Methods:Serum sCD40L and sFas(with ELISA) levels were measured in 60 patients with UAP(every stage of Ⅰ,Ⅱ,Ⅲ:20 patients) and 40 controls. Results: Levels of Serum sCD40L and sFas were significantly higher in the patients of Ⅱ, Ⅲ stage of UAP than those in controls(P0.01); in the same group,the levels of Serum sCD40L and sFas were significantly higher in the Ⅱ, Ⅲ stage of UAP than that in Ⅰ stage of UAP; these two variables were significantly positively correlated(r=0.573,P0.01). Conclusion: High levels of sCD40L and sFas have relationship with UAP. They may be contribute to the development of atherosclerotic plaque by cell apoptosis and inflammatory response. 　　[Key words] Unstable angina pectoris(UAP); soluble CD40 ligand(sCD40L); soluble Fas(sFas) 　　 　　目前研究认为，不稳定型心绞痛（Unstable Angina pectoris，UAP）的发生主要由于冠状动脉粥样斑块形成和斑块不稳定。细胞凋亡和炎症免疫反应可能参与动脉硬化斑块的发生发展[1]。我们通过检测UAP患者血清sCD40L和sFas水平变化，探讨其与UAP的关系，现将结果报道如下：