丙泊酚复合芬太尼在无痛人工流产中应用效果.docVIP

丙泊酚复合芬太尼在无痛人工流产中的应用效果 　　[摘要] 目的 研究丙泊酚复合芬太尼用于无痛人工流产麻醉时的最佳配伍方案。 方法 选取我院2014年5月～2015年8月收治的ASAⅠ～Ⅱ级行无痛人工流产患者200例，随机分为4组，每组50例。丙泊酚分别复合0.05（A组）、0.1（B组）、0.15 μg/kg（C组）的芬太尼进行人工流产麻醉，D组单纯给予丙泊酚进行麻醉。观察MAP、HR、SpO2，记录丙泊酚追加剂量、术中镇痛效果、清醒时间、术后宫缩痛及术中知晓、梦幻、恶心、呕吐等不良反应的发生率。 结果 A、B、C 组的镇痛效果优于D组，B、C组的镇痛效果优于A组（P0.05），C组术中的MAP无明显变化（P0.05），HR、SpO2均明显下降（P0.05），A、B、C组与D组术中的MAP、HR、SpO2比较，差异有统计学意义（P0.05）；B、C组的清醒时间明显短于A组（P0.05）。与D组比较，A、B、C组的丙泊酚追加剂量较少，清醒时间较短，差异无统计学意义（P0.05）。A、B、C组术后宫缩痛发生率与D组比较，差异有统计学意义（P0.05）。 结论 丙泊酚复合0.1 μg/kg的芬太尼用于无痛人工流产的麻醉效果确切、安全、并发症少，值得临床推广 。 　　[关键词] 丙泊酚；芬太尼；无痛人工流产 　　[中图分类号] R169.42 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0135-03 　　Application effect of propofol combined with fentanyl in painless artificial abortion 　　LI Xin-an1 TANG Wen-chang1 ZENG Xian-rong1 ZHANG Jia-qun1 ZOU Su-jiao2 　　1.Department of Anesthesiology，Shiyan People′s Hospital of Baoan District in Shenzhen City，Shenzhen 518108，China；2.Operation Room，People′s Hospital of Luohu District in Shenzhen City，Shenzhen 518001，China 　　[Abstract] Objective To study the best combination scheme of propofol combined with fentanyl applied in anaesthesia of painless artificial abortion. Methods 200 patients with ASA gradeⅠ-Ⅱ conducted painless artificial abortion and treated by our hospital from May 2014 to August 2015 were selected and they were randomly divided into four groups，and there were 50 cases in each group. Anaesthesia of painless artificial abortion was conducted with propofol combining with 0.05 μg/kg （group A），0.1 μg/kg （group B）， 0.15 μg/kg （group C） of fentanyl，and group D was given simple propofol to conduct anaesthesia.MAP，HR and SpO2 was observed respectively，while additional dose of propofol，analgesic effect during operation，awake time，postoperative uterine contraction pain and incidence rate of adverse reaction such as intraoperative awareness，fantasy，nausea，vomiting and so on was recorded respectively. Results Analgesic effect of group A，B and C was better than that of group D （P0.05），and MAP in gro