乙肝免疫球蛋白在预防乙肝病毒母婴传播中应用.docVIP

乙肝免疫球蛋白在预防乙肝病毒母婴传播中的应用 　　[摘要] 目的 研究乙肝免疫球蛋白在?A防乙肝病毒母婴传播中的作用。 方法 选取2013年10月～2016年5月我院疾控中心180例产前检查发现乙肝表面抗原阳性，即HbsAg阳性的孕妇及其新生儿作为观察组，选取同期没有接受乙肝免疫球蛋白预防的HbsAg阳性的孕妇及其153例，作为对照组。观察组孕妇及新生儿均使用乙肝免疫球蛋白，并对新生儿进行常规乙肝疫苗注射。对照组只对新生儿进行常规新生儿乙肝疫苗注射。统计两组新生儿出生后1、3、6个月时HbeAg、HbsAg及抗HBs的阳性率以及宫内感染率。 结果 观察组的宫内感染率与对照组相比无明显差异，差异无统计学意义（χ2=0.769，P0.05）。观察组出生1、3、6个月的HbeAg的阳性新生儿人数与对照组差异无统计学意义（P0.05）。观察组婴儿出生3个月及出生6个月后抗HBs阳性率明显高于对照组，差异有统计学意义（P0.05）。 结论 乙肝免疫球蛋白并不能有效降低宫内感染及出生后乙肝感染的发生，在预防乙肝病毒母婴传播中并无显著效果。 　　[关键词] 乙肝免疫球蛋白；乙肝疫苗；母婴传播；宫内传播 　　[中图分类号] R512.62 [文献标识码] A [文章编号] 2095-0616（2017）11-200-03 　　Application of hepatitis B immunoglobulin in the prevention of mother to child transmission of hepatitis B virus 　　YE Wenmin YU Zuwei WU Minxian YE Xiufang 　　Public Security Office， Dalang Town Community Health Service Center， Guangdong， Dongguan 523700， China 　　[Abstract] Objective To study the effect of hepatitis B immunoglobulin in the prevention of mother to child transmission of hepatitis B virus. Methods 180 cases of hepatitis B surface antigen in prenatal examination， that was， HbsAg positive pregnant women and their newborns examined in CDC of our hospital from October 2013 to May 2016 were selected as observation group. At the same time， 153 cases of HbsAg positive pregnant women， who did not receive hepatitis B immunoglobulin prophylaxis， were selected as control group. Pregnant women and newborns in observation gorup were treated with hepatitis B immunoglobulin， and the newborns were given routine hepatitis B vaccine injection. In control group， only newborns were treated with routine injection of hepatitis B vaccine. The positive rates of HbeAg， HbsAg and anti HBs and intrauterine infection rate were recorded in two groups of neonates after birth in January， March and June. Results There was no significant difference in the intrauterine infection rate between the observation group and the control group （χ2=0.769，P0.05）. There were no significant differences in the number of HbeAg positive newb