乌司他丁在糖尿病肾脏疾病患者冠状动脉造影术后对肾保护作用.docVIP

乌司他丁在糖尿病肾脏疾病患者冠状动脉造影术后对肾的保护作用 　　[摘要] 目的 研究乌司他丁在糖尿病肾脏疾病患者冠状动脉造影术后对肾的保护作用。方法 选取2014年3月～2015年3月期间在我院行冠状动脉造影术的糖尿病肾脏疾病患者62例，分为两组，研究组自造影之日起静滴乌司他丁，对照组仅静滴氯化钠，分析两组对肾保护的作用。 结果 造影后，研究组SCr升高比例、冠状动脉造影后造影剂肾病发生率等均低于对照组，比较差异有统计学意义（P0.05）；造影后第1日，两组SCr、Cys C水平均呈明显上升趋势，与造影前比较有统计学的意义（P0.05）；但研究组造影后第7日SCr、Cys C水平上升的幅度明显低于对照组，比较有统计学意义（P0.05）。 结论 乌司他丁能够进一步降低糖尿病肾脏疾病患者冠状动脉造影术后SCr、Cys C水平，保护肾功能，具有较高的临床应用价值。 　　[关键词] 乌司他丁；糖尿病肾脏疾病患者；冠状动脉造影 　　[中图分类号] R614 [文献标识码] B [文章编号] 2095-0616（2015）15-189-03 　　[Abstract] Objective To analyze the protective effect of ulinastatin in the patients with diabetic kidney disease after coronary angiography. Methods 62 cases of diabetic kidney disease patients who were given the treatment of coronary angiography in our hospital from March 2014 to March 2015 were chosen and divided into two groups，the research group and control group.The patients in the research group had been given intravenous ulinastatin from the date of radiography while those in the control group had been given only given intravenous sodium chloride.Protection of renal function of the two groups was analyzed. Results After imaging，the increased proportion of SCr，incidence of contrast-induced nephropathy after coronary angiography were lower than that of the control group，the differences were statistically significant（P0.05）；After the first day，levels of SCr and Cys C in the two groups were obviously rising， the differences were statistically significant than before（P0.05）；But seven days later，the extent levels of SCr and Cys C were significantly lower than that of the control group（P0.05）. Conclusion Ulinastatin can further reduce SCr and Cys C level of the patients with diabetic kidney disease after coronary artery angiography， and protect the renal function.As a consequence，Ulinastatin has a rather high value in clinical application. 　　[Key words] Ulinastatin；Patients with diabetic kidney disease；Coronary angiography 　　近年来，随着我国市场经济的发展和完善，人们的生活水平越来越高，冠心病、糖尿病等疾病的发病率也在逐渐增加。而随疾病的发展，糖尿病合并肾脏损害