低频重复经颅磁刺激对帕金森病患者功能障碍及情感障碍影响.docVIP

低频重复经颅磁刺激对帕金森病患者功能障碍及情感障碍的影响 　　[摘要] 目的 探讨低频重复经颅磁刺激对帕金森病患者功能障碍及情感障碍的影响。 方法 选择2014年1～12月帕金森病患者50例为研究对象，分为研究组和对照组各25例。研究组在常规治疗基础上给予低频重复经颅磁刺激治疗，对照组仅给予常规治疗。比较两组患者治疗后运动功能障碍及情感障碍。 结果 两组治疗后HAMD评分比较差异有统计学意义，研究组显著低于对照组（P0.05）；治疗后研究组HAMD评分较治疗前显著下降（P0.05）。研究组治疗后UPDRS总分及Ⅰ、Ⅱ、Ⅲ级别评分均显著下降（P0.01）；研究组治疗后UPDRS总分及Ⅰ、Ⅱ、Ⅲ级别评分均显著低于对照组（P0.01）。 结论 在常规药物治疗基础上给予低频重复经颅磁刺激能够显著改善患者功能障碍以及抑郁障碍，对患者焦虑障碍改善不明显。 　　[关键词] 低频重复经颅磁刺激；帕金森病；功能障碍；情感障碍 　　[中图分类号] R742.5 [文献标识码] B [文章编号] 1673-9701（2015）29-0061-03 　　Effect of rTMS on dysfunction and mood disorders for Parkinsons disease 　　ZHANG Fengju WANG Xiaoxue LIU Xinxin 　　Geriatrics Department， the First Affiliated Hospital of Henan University， Kaifeng 475001， China 　　[Abstract] Objective To discuss effect of rTMS on dysfunction and mood disorders for Parkinsons disease. Methods Selected 50 cases from Jan to Dec 2014 with Parkinsons disease and they were divided into study group and control group， with 25 cases of each group. Study group was treated with rTMS based on conventional treatment， and control group was treated with conventional treatment. Dysfunction and mood disorders after treatment of two groups were compared. Results After treatment， HAMD scores of study group was lower than control group（P0.05）； HAMD scores of study group after treatment was lower than before treatment（P0.05）. After treatment， UPDRS score and scores of Ⅰ， Ⅱ， Ⅲ of study group were lower（P0.01）； After treatment， UPDRS score and scores of Ⅰ， Ⅱ， Ⅲ of study group were lower than control group（P0.01）. Conclusion rTMS for Parkinsons disease based on conventional treatment can improve dysfunction and depression， but no obvious improvement in patients with anxiety disorders. 　　[Key words] rTMS； Parkinsons disease； Dysfunction； Mood disorders 　　帕金森病（parkinson’s disease，PD）是一种常见的神经系统变性疾病，老年人多见。帕金森病患者除了运动功能障碍外，还常常合并有焦虑、抑郁等情绪障碍[1，2]。用经颅磁刺激（rTMS）治疗主要是通过改变它的刺激频率而分别达到兴奋或抑制局部大脑皮质功能的目的[3，4]。本研究采用在常规药物治疗的基础上采用低频重复经颅磁刺激治疗帕金森病，评价患者低频重复经颅磁刺激对患者功能障碍及情感障碍的影响，现报道如下。 　　1 资料与方法 　　1.1 一般资料