以艾司奥美拉唑为基础四联疗法对Hp阳性十二指肠溃疡疗效观察.docVIP

以艾司奥美拉唑为基础四联疗法对Hp阳性十二指肠溃疡的疗效观察 　　[摘要] 目的 研究不同剂量艾司奥美拉唑联合铋剂四联疗法对幽门螺杆菌（Hp）阳性十二指肠溃疡的临床疗效。 方法 选取2017年1～8月我院消化科门诊确诊的Hp阳性十二指肠溃疡活动期患者68例，随机分为对照组与研究组，各34例。在给予两组患者胶体果胶铋胶囊+阿莫西林胶囊+克拉霉素分散片基础上，再给予不同剂量艾司奥美拉唑镁肠溶片，疗程10 d，10 d后给予相同剂量艾司奥美拉唑镁肠溶片继续治疗4周。比较治疗后两组患者溃疡的愈合情况、Hp根除率及不良反应发生率。 结果 两组治疗溃疡的总有效率分别为94.1%、97.1%，两组比较差异无统计学意义（P0.05），但研究组与对照组显效率分别为79.4%、61.8%，Hp根除率分别为91.2%、82.4%，研究组显效率及Hp根除率明显高于对照组（P0.05）。 结论 大剂量艾司奥美拉唑联合铋剂四联疗法能提高Hp根除率，有效促进十二指肠溃疡的愈合。 　　[关键词] 幽门螺杆菌；十二指肠溃??；艾司奥美拉唑；四联疗法 　　[中图分类号] R573.1 [文献标识码] B [文章编号] 1673-9701（2017）32-0103-03 　　[Abstract] Objective To study the clinical efficacy of different doses of esomeprazol combined with bismuth quadruple therapy on helicobacter pylori（Hp） -positive duodenal ulcer. Methods 68 patients with Hp - positive duodenal ulcer in the active period diagnosed in the gastroenterology clinic from January 2017 to August 2017 were randomly divided into control group （n=34） and study group （n=34）. The two groups were treated with different doses of esomeprazole magnesium enteric-coated tablets based on colloidal pectin bismuth capsules + amoxicillin capsules+ clarithromycin dispersible tablets， and course was 10 days. After 10 days， the same dose of esomeprazole magnesium enteric-coated tablets was given 4 weeks of continuous treatment. The ulcer healing， Hp eradication rate and the incidence of adverse reactions between the two groups were compared after treatment. Results The effective rates of the two groups were 94.1% and 97.1%， respectively. There was no significant difference（P0.05）.The effective rate of the study group and the control group were 79.4% and 61.8% respectively. And the Hp eradication rates in the two groups were 91.2% and 82.4%（P0.05）. Conclusion High dose of esomeprazol combined with bismuth quadruple therapy can improve Hp eradication rate and promote the healing of duodenal ulcer effectively. 　　[Key words] Helicobacter pylori； Duodenal ulcer； Esomeprazole； Quadruple therapy 　　消化性溃疡是临床引起腹痛或上消化道出血的常见疾病之一，胃酸的存在和幽门螺杆菌（Helic