探究高血压患者血糖异常与内皮祖细胞CD34+水平相关性及对IMT的影响.docVIP

探究高血压患者血糖异常与内皮祖细胞CD34+水平相关性及对IMT的影响 　　doi：10.3969/j.issn.1007-614x.2014.11.77 　　摘 要 目的：探究高血压患者血糖异常与内皮祖细胞CD34+水平相关性及对IMT（动脉内膜中层厚度）的影响。方法：收治原发性高血压（EH）患者80例，经血糖检测，分为EH并发血糖调节异常组（n=54例）和EH并血糖正常（NBG）组（n=26例），健康组选择21例健康人，经全自动流式细胞仪监测各组EPCs CD34+水平，采用统计SPSS20.0分析组间EPCs CD34+水平差异。结果：高血压血糖异常组CD34+显著低于高血压血糖正常组和健康组（P0.05）；年龄与冠状动脉IMT呈正相关（P0.05）。结论：高血压患者血糖水平异常时，PCs CD34+水平会明显下降，血糖异常与IMT异常无显著关联，而内皮祖细胞CD34+水平与IMT变化呈负相关性。因此，内皮祖细胞CD34+水平可作为动脉内膜中层厚度变化的评定指标，可能能够作为冠心病的预测因子。 　　关键词 原发性高血压 血糖异常 内皮祖细胞CD34+ 动脉内膜中层厚度 相关性 　　Exploration of the correlation between abnormal blood glucose and CD34+ levels of endothelial progenitor cells of hypertensive patients and the influence to IMT 　　Li Bin，Hu Wenfei，Wang Furui，Li Bo，Hu Xiaomin 　　The Peoples Hospital of Luquan City，Hebei 050200 　　Abstract Objective：To explore the correlation between abnormal blood glucose and CD34+ levels of endothelial progenitor cells of hypertensive patients and the influence to IMT.Methods：80 patients with essential hypertension were selected.Through the detection of blood glucose，they were divided into the EH complicated with hyperglycemia group（n=54 cases） and the EH complicated with normal blood glucose group（NBG）（n=26 cases）.21 cases of healthy people were selected as the health group.Each group of EPCs CD34+ levels were detected with automatic flow cytometry.The differences of EPCs CD34+ levels among groups were compared using SPSS 20.Results：In EH complicated with hyperglycemia group，blood CD34+ was significantly lower than that of the EH complicated with normal blood glucose group and the healthy group（P0.05）；Age was positively correlated with coronary artery IMT（P 　　Key words Essential hypertension；Abnormal blood glucose；Endothelial progenitor cell CD34+；Intima media thickness；Relevance 　　原发性高血压往往并发动脉血管壁厚度变化进而引发冠心病[1]。相关研究证实原发性高血压患者早期内皮祖细胞会发生损伤，使血管舒张作用下降。越来越多研究证实：原发性高血压患者常并发血糖水平异常，与糖尿病患病有一定的相关性。于是我们猜想，对于高血压患者内皮祖细胞的功能损伤与血糖水平的异常是否具有相关性。是不是可以通过内皮祖细胞的损伤情况联合血糖水平变化来预测动脉血管管壁的厚度异常，从而预防冠心病发病。2012年8月-2013年10月收治原发性高血