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目录
吡咯类海洋生物碱Neolamellarin A 类似物的设计、合成与活性评价
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1 文献综述································································ 1
1.1 Neolamellarin A 及其结构相似化合物的结构与活性·····················································1
1.1.1 引言······················································································································· 1
1.1.2 Neolamellarins 的结构及活性研究·······················································2
1.1.3 Neolamellarin A 类似物的活性介绍·····················································3
1.2 MDR 逆转剂简介··············································································································5
1.3 热休克蛋白 Hsp 90 及其抑制剂·········································································10
1.3.1 热休克蛋白 Hsp 90 简介··········································································10
1.3.2 热休克蛋白 Hsp 90 抑制剂·····································································14
1.4 1,3,4-取代吡咯环的构建方法研究····································································19
1.4.1 1,2,3,5-取代吡咯环构建··········································································19
1.4.2 2.3,4-取代吡咯环的构建··········································································19
1.4.3 Tani 等人的3,4-取代吡咯环构建方法················································20
1.4.4 Neolamellarin A 的全合成·······································································20
1.4.5 通过环状氮杂二烯的Diels-Alder 反应构建3,4位带有相同取代
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