单次大量饮酒和ALDH2基因多态性与OSAHS病情相关性研究.docVIP

单次大量饮酒和ALDH2基因多态性与OSAHS病情相关性研究 　　[摘要]目的 探?单次大量饮酒后不同时间段内阻塞性睡眠呼吸暂停低通气综合征（OSAHS）男性患者的病情变化。方法 选取2014年1月～2016年12月武汉市第三医院耳鼻咽喉科就诊武汉地区汉族男性42例健康成人（对照组）和50例OSAHS患者（OSAHS组），即刻大量饮酒前后进行多导睡眠呼吸监测，并检测其外周血ALDH2基因多态性。结果 OSAHS组的BMI高于对照组（P0.05）。OSAHS组不同ALDH2基因型之间AHI指数、最低血氧饱和度在饮酒前后差异均无统计学意义（P0.05）。结论 单次饮大量酒后3～5 h内会加重OSAHS患者的病情，其与ALDH2基因多态性无显著相关性。 　　[关键词]阻塞性睡眠呼吸暂停；饮酒；乙醛脱氢酶2；基因多态性 　　[中图分类号] R766.49 [文献标识码] A [文章编号] 1674-4721（2017）09（b）-0019-05 　　Association analysis between single massive drinking and polymorphism of ALDH2 gene and OSAHS disease 　　WANG Bin-ru1 ZHANG Yan2 LIANG Geng-tian1 　　1.Department of Otorhinolaryngology，Tongren Hospital of Wuhan University The Third Hospital of Wuhan City，Hubei Province，Wuhan 430060，China；2.Department of Pharmacy，Tongren Hospital of Wuhan University The Third Hospital of Wuhan City，Hubei Province，Wuhan 430060，China 　　[Abstract]Objective To explore the change of condition of obstructive sleep apnea-hypopnea syndrome （OSAHS） in male patients after different time periods of single massive drinking.Methods 42 healthy males with Han nationality in Wuhan area （the control group） and 50 patients with OSAHS （the OSAHS group） in the otolaryngology department of the Third Hospital of Wuhan City from January 2014 to December 2016 were selected.Polysomnography （PSG） monitoring was performed immediately before and after massive drinking，and the peripheral blood of aldehyde dehydrogenase-2 was detected.Results The BMI in the OSAHS group was higher than that of the control group （P0.05）.The index of AHI and LSaO2 of different ALDH2 genotypes in the OSAHS group showed no statistical differences before and after drinking （P0.05）.Conclusion In 3-5 hours，single massive drinking can aggravate OSAHS patients′ condition，which is not significantly associated with ALDH2 gene polymorphism. 　　[Key words]Obstructive sleep apnea-hypopnea syndrome；Drinking；Aldehyde dehydrogenase-2；Gene polymorphism 　　饮酒与阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea-hypopnea syndrome，OSAHS）关