同步与序贯化放疗在食管癌治疗中应用.docVIP

同步与序贯化放疗在食管癌治疗中应用 　　【摘要】 目的：研究同步与序贯化放疗在食管癌治疗中的临床效果和安全性，找到治疗食管癌的最佳方法，降低复发率，有效提高癌症的生存率。方法：选取本院2011年6月-2014年6月收治的食管癌患者100例，将其作为临床研究对象，采用随机数字表法将其分为两组，对照组采用序贯化放疗进行治疗，即在两个疗程化疗后进行放疗；试验组采用同步化放疗进行治疗，即在治疗的第1天起同时进行化疗和放疗，对比两组的临床疗效，同时对治疗过程中出现的不良反应进行详细记录后对比分析，出院后对所有参加本次实验的患者进行为期3年的随访。结果：试验组显效20例，有效28例，无效2例，总有效率为96.00%，对照组显效15例，有效20例，无效15例，总有效率为70.00%，两组比较差异有统计学意义（P0.05）。结论：采用同步化放疗治疗食管癌的临床效果较为明显，治疗过程中出现的不良反应高于序贯化放疗，但不良反应均在患者可承受的范围内，整个过程未出现严重后果，安全可靠，患者以及患者家属较为满意，因此值得在临床上进行继续探讨和广泛应用。 　　【关键词】 食管癌； 同步放化疗； 序贯化放疗 　　【Abstract】 Objective：To study clinical therapeutic effect of the simultaneous and sequential chemoradiotherapy in patients with esophageal carcinoma and safety，to find the best method of treatment of esophageal cancer，reduce the recurrence rate，improve the survival rate of cancer.Method：100 patients with esophageal cancer in our hospital from June 2011 to June 2014 selected the cases admitted as the clinical research object，randomly divided into two groups，the control group were treated with radiotherapy，namely in the two course of chemotherapy，radiotherapy；the test group was treated with concurrent chemoradiotherapy treatment at the same time，namely the chemotherapy and radiotherapy on the first day of treatment，were compared after treatment，compared to patients with clinical curative effect， and adverse reactions during the treatment of the contrast and analysis of the detailed record， after discharge for a period of three years of follow-up for all patients participating in this experiment.Result：The test group with concurrent chemoradiotherapy treatment markedly 20 cases，effective 28 cases，invalid 2 cases，the total effective was 96.00%，the control group used sequential chemoradiotherapy for treatment of 15 cases markedly effective， effective 20 cases， invalid 15 cases， the total effective was 70.00%， the difference between the two groups was statistically significant（P0.05）.Conclusion：Using the clinical effect of concurrent chemoradiotherapy in the treatment of esopha