右丙亚胺联合CAG方案治疗老年急性髓细胞白血病疗效观察.docVIP

右丙亚胺联合CAG方案治疗老年急性髓细胞白血病疗效观察 　　【摘要】目的 评价和比较右丙亚胺联合 CAG方案与单用CAG方案治疗老年急性髓细胞白血病的临床疗效和不良反应。方法 2010年 1月至2012年 6月共入组 30例老年急性髓细胞白血病患者，随机分入 D―CAG方案组与 CAG方案组，每组各 15例，比较两组的完全缓解率、总体缓解率以及不良反应情况。结果D―CAG方案组与 CAG方案组的完全缓解率相似 （70%vs67%，P=0.752）。血液学毒性、胃肠道反应、肝。肾功能异常指标两组差异均没有统计学意义，但 D―CAG组患者心 肌受损指标肌钙蛋白 I和心脏超声的心肌活动指数 （Tei指数 ）低于 CAG组 （0.10vs0.13，P=0.021；0.45vs0.50，P0.01），差异有统计学意义。两组心电图异常发生率差异无统计学意义 （25%vs30%，P=0.723）。结论 D―CAG方案是治疗老年急性髓细胞白血病患者的有效方案之一，其中右丙亚胺可在不影响疗效的前提下能有效减轻化疗相关的心脏毒性。 　　【关键词】急性髓细胞白血病；右丙亚胺；化疗；老年患者 　　【Abstract】objective to evaluate and compare the right c imine joint the CAG plan and use the CAG treatment of elderly acute myelogenous leukemia （clinical curative effect and adverse reactions. Methods between January 2010 and June 2012， the group of 30 cases of elderly patients with acute myelogenous leukemia， randomly assigned into D - the CAG scheme and the CAG group， each group of 15 cases， compared two groups of complete response rate， the overall response rate and adverse reactions. Results D - the CAG solutions group and the CAG group of complete remission rate is similar （70% vs67 %， P = 0.752）. Hematology toxicity， liver， gastrointestinal tract reaction. Abnormal renal function index difference between the two groups were not statistically significant， but D - the CAG patients of heart muscle damage index troponin I and echocardiographic myocardial activity index （Tei index） is lower than the CAG group （0.10 vs0.13， P = 0.10； 0.45 vs0.50，P 0.01）， the difference was statistically significant. The incidence of abnormal ecg similar between the two groups have no statistical significance （vs30%25%， P = 0.723）. Conclusion D - the CAGCase is the treatment of elderly patients with acute myelogenous leukemia （one of the effective solutions， including c imine right can be on the premise of not affect curative effect can effectively reduce the phase of chemotherapyClose the cardiac toxicity. 　　【key words 】acute myelogenous leukemia. C imine right； Chemotherapy； Elderly patient