来士普联合认知疗法治疗老年抑郁症的疗效及安全性分析.docVIP

来士普联合认知疗法治疗老年抑郁症的疗效及安全性分析 　　[摘要] 目的 探讨来士普联合认知疗法治疗老年抑郁症的临床疗效和安全性。方法 我院诊治的84例老年抑郁症患者，随机将其分为对照组（来士普治疗）和观察组（来士普联合认知疗法治疗），每组各42例，根据汉密顿抑郁量表（HAMD）及生活指数评分指数（QLI），对两组治疗前后抑郁程度及生活质量进行观察和比较，并监测治疗期间不良反应。结果 与对照组相比，治疗后观察组HAMD评分明显降低（25.0±4.0 vs 33.5±4.5），QLI评分明显升高（8.7±1.5 vs 6.2±1.2），P0.05；治疗期间，两组都没有出现明显不良反应。结论 对于老年抑郁症患者，来士普联合认知疗法治疗明显改善患者的抑郁程度和生活质量，值得临床推广。 　　[关键词] 来士普；认知疗法；老年抑郁症；疗效 　　[中图分类号] R749.4 [文献标识码] B [文章编号] 2095-0616（2014）04-103-03 　　Efficacy and safety analysis of lexapro combined with cognitive therapy for patients with senile depression 　　DU Weihao 　　Xinyong Hospital in Dongguan City，Dongguan 523230，China 　　[Abstract] Objective To study the clinical efficacy and safety of lexapro combined with cognitive therapy for patients with senile depression. Methods 84 patients with senile depression were randomized into the control group（lexapro treatment） and the observation group（lexapro combined with cognitive therapy）， 42 patients per group. The depression level and life quality in the two groups between pre-treatment and post-treatment were observed and compared according to the hamilton depression scale（HAMD） and quality of life index（QLI）. The adverse reaction in the two groups during the treatment period was monitored. Results Compared with the control group， the HAMD scores were obviously decreased（25.0±4.0 vs 33.5±4.5） and QLI scores were significantly increased（8.7±1.5 vs 6.2±1.2） in the observation group on the post-treatment， P0.05； there were no obvious adverse reactions during the treatment period. Conclusion For the patients with senile depression， the treatment of lexapro combined with cognitive therapy can significantly improve the depression level and life quality and is worthy of clinical promotion. 　　[Key words] Lexapro；Cognitive therapy；Senile depression；Efficacy 　　老年抑郁症作为临床常见疾病之一，严重影响着患者的生活质量[1]。大量研究表明，单纯抗抑郁药物治疗虽然能够一定程度上改善抑郁症状，但是同时具有较高的复发率和较多不良反应，很大程度上影响着治疗的整体疗效[2]。认知疗法是针对患者的焦虑、抑郁情绪及不合理认知所致的心理问题，通过认知和行为技术，矫正患者的不良认知和行为。 　　1 资料与方法 　　1.1 一般资料 　　201