氟哌噻吨美利曲辛联合埃索美拉唑治疗难治性胃食管反流病的临床疗效观察.docVIP

氟哌噻吨美利曲辛联合埃索美拉唑治疗难治性胃食管反流病的临床疗效观察 　　[摘要] 目的 探讨氟哌噻吨美利曲辛联合埃索美拉唑治疗难治性胃食管反流病的临床疗效。 方法 2012年9月～2014年12月，选择60例难治性胃食管反流病患者为研究对象，随机分为观察组和对照组，每组30例。观察组给予氟哌噻吨美利曲辛联合埃索美拉唑治疗，对照组给予埃索美拉唑治疗，比较两组的临床疗效。 结果 治疗后，两组的GERDQ、PSQI、HAMA、HAMD评分较治疗前下降，但对照组治疗前后比较，差异无统计学意义（P0.05），治疗后，观察组的GERDQ、PSQI、HAMA、HAMD评分显著低于对照组（P0.01）。观察组和对照组的总有效率分别为93.3%和63.3%，差异有统计学意义（χ2=6.285，P0.05）。 结论 氟哌噻吨美利曲辛联合埃索美拉唑治疗难治性胃食管反流病，能够显著提高临床疗效。 　　[关键词] 氟哌噻吨美利曲辛；埃索美拉唑；难治性胃食管反流病 　　[中图分类号] R581.9 [文献标识码] A [文章编号] 1674-4721（2016）02（a）-0038-04 　　Clinical effect observation of flupenthixol and melitracen combined with esomeprazole in the treatment of refractory gastroesophageal reflux disease 　　CHEN Xiao-feng1 WU Yu-long2 LI Qiu-yuan1 　　1.Department of Gastroenterology，the First Affiliated Hospital of Shantou University Medical College in Guangdong Province，Shantou 515041，China；2.Department of Gastroenterology，Shantou Chaonan Minsheng Hospital in Guangdong Province，Shantou 515144，China 　　[Abstract] Objective To explore the clinical effect of flupenthixol and melitracen combined with esomeprazole in the treatment of refractory gastroesophageal reflux disease. Methods From September 2012 to December 2014，60 patients with refractory gastroesophageal reflux disease were selected as research group，and they were randomly divided into observation group and control group，and there were 30 patients in each group.The observation group was given flupenthixol and melitracen combined with esomeprazole，and the control group was given esomeprazole alone.The clinical effect was compared between two groups. Results GERDQ，PSQI，HAMA and HAMD score in two groups after treatment was reduced respectively compared with that before treatment，but the difference was not statistically significant compared before and after treatment in the control group （P0.05）.GERDQ，PSQI，HAMA and HAMD score in observation group after treatment was significantly lower than that in control group （P0.01）.The total effective rate in observation group and control grou