大株红景天注射液对急性心肌梗死患者血清LDL―Chs―CRP影响.docVIP

大株红景天注射液对急性心肌梗死患者血清LDL―Chs―CRP影响 　　【摘要】目的 观察大株红景天注射液对急性心肌梗死患者血清低密度脂蛋白（LDL-C）、高敏C-反应蛋白（hs-CRP）的影响以探讨其药理作用。方法 115例急性心肌梗死患者随机分为两组，治疗组（n=57）和对照组（n=58）；两组均给予常规治疗，治疗组在此基础上给予静点大株红景天注射液10 ml/d，连续两周。观察治疗前后血清LDL-C、hs-CRP水平的变化。结果 1.与治疗前比较，治疗组和对照组治疗后血清LDL-C、hs-CRP水平显著下降，差异有统计学意义（P0.05）。2.治疗2周后，治疗组血清LDL-C、hs-CRP与对照组比较差异有统计学意义（P0.05）。结论 大株红景天注射液能使急性心肌梗死患者的血清LDL-C、hs-CRP更快恢复至正常水平，其机制可能与阻断动脉粥样硬化的炎症反应过程有关。 　　【关键词】急性心肌梗死；动脉粥样硬化；LDL-C；hs-CRP 　　【中图分类号】R47 【文献标识码】B 　　Study on the influence of serum LDL-C and hs-CRP of patients with acute myocardial infarction with Sofren Injection 　　SHI Hui-rong1， WANG De-wei1， ZHAO Dan-dan2， LIU Quan-liang1， 　　LIU Guo-hong1， HUANG Jie1， LI Jun-feng1 　　（1.Second Department of Cardiology， People’s Hospital of Fengrun District， Tangshan City， Hebei Tangshan 064000， China； 2.School of Public Health， Hebei United University， Hebei Tangshan， 063009，China） 　　【Abstract】Objective To explore the influence and significance of serum LDL-C and hs-CRP of patients with acute myocardial infarction with Sofren injection. Methods 115 patients were randomly divided into two groups， 58 cases as treatment group and 57 cases as control group； The two groups were given conventional therapy，and the treatment group was given Sofren Injection 10 mL intravenous drip based on routine treatment， 1 time a day. The two groups were treated for 2 weeks. then the content of serum LDL-C and hs-CRP of two groups were analyzed. Results 1.The treatment group and the control group after treatment serum LDL-C and hs-CRP all decreased， The difference was statistically significant （P0.05）2. The content of serum LDL-C and hs-CRP of treatment group were all lower than those of control group after 2 weeks of treatment. （P0.05） Conclusion Sofren Injection can cause the acute myocardial infarction patients with serum LDL-C， hs-CRP quickly returned to normal level. The mechanism may be related to the blocking inflammatory reaction of atherosclerosis. 　　【Key words】Acute myocardial infarctio