妇科千金片对阿奇霉素在慢性盆腔炎大鼠体内药物动力学影响お.docVIP

妇科千金片对阿奇霉素在慢性盆腔炎大鼠体内药物动力学影响お 　　[摘要] 研究妇科千金片对阿奇霉素（AZM）在慢性盆腔炎大鼠体内多次给药药物动力学的影响，评价联合用药的合理性。以雌性SD大鼠为实验对象，采用子宫内接种混合菌液加机械损伤法建立慢性盆腔炎动物模型。将模型大鼠随机分为对照组和联合用药组，对照组灌胃给予阿奇霉素10 mg?kg-1?d-1，联合用药组给予等剂量阿奇霉素2 h后灌胃妇科千金片166 g?kg-1?d-1，每日1次，连续7 d。于不同时间点采集血浆样本，HPLCMS测定血浆中阿奇霉素浓度。采用ADAPT 51软件反向高斯模型计算药动学参数，SPSS软件对各组参数进行统计学分析。结果显示妇科千金片对阿奇霉素的药动学参数CLt，CLd，MIT，F均无显著影响，研究表明临床妇科千金片与阿奇霉素联合应用于慢性盆腔炎的治疗具有一定的合理性。 　　[关键词] 妇科千金片； 阿奇霉素； 多次给药； 药动学； 联合用药 　　Effect of Fuke Qianjin tablets on pharmacokinetics of Azithromycin in 　　rats with chronic pelvic inflammatory disease 　　LI Wei1， ZOU Liang1*， GONG Yun2， ZHANG Peng2， WANG Ping3， ZHANG Yan3， QIU Lu1 　　（1 Chengdu University， Chengdu 610106， China； 　　2 Zhuzhou Qianjin Pharmaceutical Co， Ltd， Zhuzhou 412003， China； 　　3 Chengdu University of Traditional Chinese Medicine， Chengdu 611137， China） 　　[Abstract] To investigate the effect of Fuke Qianjin tablets on the pharmacokinetics of Azithromycin（AZM） in rats with chronic pelvic inflammation， and evaluate the rationality of the drug combination The animal models of chronic pelvic inflammatory disease were established by intrauterine injection of mixed bacterial suspension plus mechanic injury in female SpragueDawley（SD） rats The model rats were randomly divided into control group and drug combination group The rats in control group were given with Azithromycin 10 mg?kg1?d1 by intragastric administration， while the rats in drug combination group were given with Fuke Qianjin tablets 166 g?kg1?d1by intragastric administration 2 hours after the equivalent dose of azithromycin， once a day， consecutively for 7 days Plasma samples were collected at different time points and the concentration of AZM in plasma was determined by high performance liquid chromatography coupled with mass spectrometry（HPLCMS） ADAPT 51 software was used to calculate the pharmacokinetic parameters of each group by Inverse Gaussian Function model SPSS software was used for the statistical analysis of data in each group The results show