TF方案和FOLFOX6方案治疗晚期胃癌的临床观察-肿瘤学(内科)专业论文.docxVIP

新疆医科大学硕士学位论文 新疆医科大学硕士学位论文 1 1 TF 方案和 FOLFOX6 方案治疗晚期胃癌的临床观察 研究生：彭媛媛 导师：唐勇 副教授 摘 要 目的：比较 TF 方案和 FOLFOX6 方案治疗晚期胃癌的疗效及不良反应。方法： 回顾性分析我院 54 例经病理确诊的晚期胃癌患者。A 组 28 例，采用 TF 化疗方案： 多西他赛 50mg/m2，d1；CF400 mg/m2，d1；5-FU40 mg/m2，d1，5-FU2400～3000 mg/m2， CⅣ(46 小时)，每 14 天为一周期，B 组 26 例，采用 FOLFOX6 方案化疗：L-OHP100 mg/m2，d1；CF400 mg/m2，d1；5-FU400 mg/m2，d1，5-FU 2400-3000 mg/m2，CⅣ(46 小时)，每 14 天为一周期，对两组的近期疗效、生活质量改善情况、总生存期、无疾 病进展时间、不良反应进行比较。结果：A 组和 B 组的有效率分别为 46.40%和 46.20%， 差异无统计学意义(P=0.99)。A 组和 B 组的无疾病进展时间分别为 5.5 月，差异无统 计学意义 (P=0.54)。中位生存时间分别 8.0 月和 8.5 月，差异无统计学意义(P=0.71)， A 组和 B 组的生活质量改善为 64.3%和 30.80%差异有统计学意义 (P=0.04)；两组主 要不良反应白细胞减少、血红蛋白减少、恶心、呕吐、便秘等指标的差异具有显著 性(P＜0.05)。结论：TF 方案和 FOLFOX6 方案在晚期胃癌的治疗方面近期疗效比较 好，在不良反应以及生活质量改善情况等方面，TF 方案优于 FOLFOX6 方案，具有 更好的耐受性。 关键词：晚期胃癌；化学治疗；TF 方案；FOLFOX6 方案； 2 2 TF regimen and FOLFOX6 regimen on advanced gastric carcinoma in advanced gastric cancer Postgraduate：Peng Yuanyuan Supervisor：Associate Prof. Tang Yong Abstract Objective: To compare the efficacy and toxicity of TF regimen and FOLFOX6 regimen on advanced gastric carcinoma (AGG) in gastric cancer. Methods: Retrospective analysis of 54 cases confirmed by pathology in patients with advanced gastric cancer,28 patients in group A treated with DF regimen:Docetaxel 50mg/m2,d1;CF400mg/m2,d1;5-FU400mg/ m2,d1;5-FU2400～3000mg/m2,CⅣ(46h), were given, repeated every 14 days; 26 patients in group B treated with FOLFOX6 regimen:L-OHP100 mg/m2,d1;CF400mg/m2,d1; 5-FU400mg/m2,d1;5-FU2400 ～ 3000mg/m2,CⅣ(46h), were given, repeated every 14 days.The efficacy,Progression Free Survival(PFS),overall survival (OS) ,improvement of QOL and toxicity of the two regimens were analyzed. Results: The response rate (RR) of group A and B were 46. 40%and 46.20%,Difference was statistically significant(P =0.99). The median PFS was 5.50months in group A and5.50months in group B(P =0.54).The median survival time was 8.00 months in group A and 8.50 months in group B,Difference was statistically significant(P =0.71).The improvement