STI571对阿尔茨海默病模型大鼠神经保护作用及其抗凋 亡机制的研究-神经病学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要·········································································································1 英文摘要·········································································································3 英文缩写·········································································································5 研究论文 STI571 对阿尔茨海默病模型大鼠神经保护作用及其抗凋亡机 制的研究 前言··········································································································6 材料与方法······························································································8 结果········································································································17 附图········································································································19 附表········································································································28 讨论········································································································29 结论········································································································31 参考文献································································································32 综述 EphA4 在神经变性疾病中的研究进展 35 致谢················································································································46 个人简历········································································································47 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 STI571 对阿尔茨海默病模型大鼠神经保护作用及其抗凋亡机制 的研究 摘 要 目的 ： 近 来 研 究 显 示 干 扰 素 信 号 途 径 分 子 在 过 度 表 达 c-Abl 的 AblPP/tTA 转基因鼠脑组织神经元丢失病理机制中发挥重要作用，设计本 实验的目的是研究阿尔茨海默病（Alzheimer’s disease，AD)模型大鼠非受 体酪氨酸激酶 c-Abl 与信号传导及转录激活因子 1（signal transducer and activator of transcription-1 ，STAT1）的表达情况，并观察选择性 c-Abl 抑 制剂 STI571 对其表达的影响，为 c-Abl 成为 AD 潜在的治疗靶点提供更 多的证据。 方法：健康雄性 SD 大鼠 48 只，随机分为 4 组，即假手术组、Aβ1-42 组、假手术+STI571 组、Aβ1-42+STI571 组，双侧海马 CA1 区分别注射 10mg 凝聚态