沙培林雾化吸入联合NP方案对晚期非小细胞肺癌疗效观察及T细胞亚群影响.docVIP

沙培林雾化吸入联合NP方案对晚期非小细胞肺癌疗效观察及T细胞亚群影响 　　【摘要】 目的：观察沙培林雾化吸入联合NP方案治疗晚期非小细胞肺癌的临床疗效及其对T细胞亚群的影响。方法：选取本院收治的晚期非小细胞肺癌患者68例，随机分为沙培林雾化吸入联合NP方案组（O-NP组）及单纯NP方案组（NP组），每组各34例，比较两组治疗后的临床疗效及T细胞亚群水平。结果：O-NP组的临床疗效明显优于NP组，两组比较差异有统计学意义（P0.05）；O-NP组治疗后T细胞亚群水平明显优于治疗前，也明显优于NP组，差异均有统计学意义（P0.05）。结论：沙培林雾化吸入联合NP方案治疗晚期非小细胞肺癌的疗效显著，可有效改善患者免疫功能，值得临床推广应用。 　　【关键词】 沙培林； 雾化吸入； NP方案； 晚期； 非小细胞肺癌； T细胞亚群 　　【Abstract】 Objective：To observe the clinical effect of Sapylin inhalation combined with NP regimen for the treatment of advanced non-small cell lung cancer and its effects on the T lymphocyte subsets.Method：68 cases of advanced non-small cell lung cancer in our hospital were selected，they were randomly divided into inhalation combined with NP regimen group （O-NP group） and NP regimen alone group （NP group）， 34 cases in each group. The clinical efficacy of the two groups after treatment and the level of T cells subsets before and after treatment were compared.Result：The clinical effect of O-NP group was significantly better than that of NP group，the difference was statistically significant（P0.05）.In O-NP group，the T cells subgroup level after treatment was significantly better than before，and it was also significantly better than that in NP group，the differences were statistically significant（P0.05）.Conclusion：Sapylin inhalation combined with NP regimen for the treatment of advanced non-small cell lung cancer is effective，can effectively improve the immune function，it is worthy of clinical application. 　　【Key words】 Sapylin； Inhalation； NP regimen； Advanced； Non-small cell lung cancer； T cell subsets 　　First-author’s address：Cancer Hospital of Ganzhou，Ganzhou 341000，China 　　doi：10.3969/j.issn.1674-4985.2015.28.012 　　肺癌是世界上最常见的恶性肿瘤之一，已成为我国城市人口恶性肿瘤死亡原因的第1位[1]。其中非小细胞肺癌约占所有肺癌的80.0%，约75.0%的患者发现时已处于中晚期，5年生存率很低[2]。本院针对晚期非小细胞肺癌患者采用沙培林雾化吸入联合NP方案治疗，疗效满意，现报告如下。 　　1 资料与方法 　　1.1 一般资料 选取1999年10月-2010年9月份本院收治的晚期非小细胞肺癌患者68例，按入院先后顺序随机分为沙培林雾化吸入联合NP方案组（O-NP组）及单纯NP方案组（NP组），每组各34例患者。O-NP组中男19例，女15例；年龄25～65岁，平均（45.3±3.