心衰的诊断进展.ppt

* 究竟BNP是一类什么样的物质呢？它是促尿钠排泄缩氨酸家族（NPS）的一员 The Triage? BNP Test is indicated for use as an aid in the diagnosis of congestive heart failure. * Id.-No. 1 299 832 1 489 020 1 552 007 1 777 8661 777 882 Bottle 12 12 12 12 Contents Buffer 4 x 15 mLAntibody 4 x 18 mL Buffer 3 x 70 mLAntibody 3 x 84 mL Buffer 6 x 16.5 mLAntibody 6 x 20 mL Buffer 3 x 250 mLAntibody 3 x 300 mL Analyzer Roche/Hitachi 704, 717, 911/912 Roche/Hitachi 717, 911/912 Roche/Hitachi 917, Modular P Roche/Hitachi 747 Product Also required: Precinorm? RF Precipath? RF Precimat? RF Id.-No. 1 171 275 1 661 396 1 447 971 Kit Size 3 x 1 mL 3 x 1 mL 3 x 0.5 mL Stability Shelf life Reagents on board Calibration 15 months 35 days 28 days * Listed here are the three common natriuretic peptides. Structurally, the natriuretic peptides are similar. All have a 17 AA ring structure with 11 identical AA. This ring structure is essential for receptor binding (Guanylate cyclase linked receptor). The first natriuretic peptide that was identified in the late 1960s was the Atrial Natriuretic Peptide , a 28-amino acid hormone found predominantly in the atrium of the heart. ANP is increased in volume overload conditions in normal patients, as well as patients with CHF. The B-type, or formerly called Brain Natriuretic Peptide, has been found to be a more useful marker for congestive heart failure because the hormone is elevated in patients with congestive heart failure. BNP is secreted from the ventricles of the heart in response to ventricular stretch and volume overload. BNP has been synthesized and developed as a therapeutic tool for use in congestive heart failure. The C-type natriuretic peptide is found in the endothelium of the heart, has a very low concentration in plasma, and is not elevated in CHF. Other members of the natriuretic peptide family such as Urodilatin are still being identified and characterized. This family of hormonally active peptides clearly has a regulatory role in cardiovas