帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作效果评价.docVIP

帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作效果评价 　　[摘要] 目的 研究帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作的效果。方法 病例来源：方便选取该院2014年4月―2015年2月住院接受治疗的60例伴精神病症状抑郁发作患者。患者分组方法：随机抽签法。60例患者分为抗抑郁组和联合干预组两个组别。抗抑郁组以帕罗西汀单药治疗；联合干预组以帕罗西汀、氨磺必利联用药治疗。观察指标：①总有效率；②用药副反应率；③治疗前和治疗后患者汉密尔顿抑郁量表评分的差异。结果 ①联合干预组相比于抗抑郁组总有效率更高，分别为93.33%和66.67%，差异有统计学意义（P0.05）；③治疗前两组汉密尔顿抑郁量表评分相似，差异无统计学意义（P0.05）；治疗后联合干预组相比于抗抑郁组汉密尔顿抑郁量表评分改善更显著，差异有统计学意义（P0.05）。结论 帕罗西汀联合氨磺必利治疗伴精神病症状抑郁发作的效果确切，可有效改善患者抑郁症状，用药安全可靠，值得推广。 　　[关键词] 帕罗西汀；氨磺必利；伴精神病症状抑郁发作；效果 　　[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742（2016）05（b）-0023-03 　　[Abstract] Objective To research the effect of paroxetine and amisulpride in treatment of depressive episode with schizophrenic symptoms. Methods 60 cases of patients with depressive episode with schizophrenic symptoms hospitalized in our hospital from April 2014 to February 2015 were selected and randomly divided into two groups， the anti-depression group were treated with single paroxetine， the combined intervention group were treated with paroxetine and amisulpride， and the total effective rate， side reaction rate of medication and the difference in the Hamilton depression rating scale score before and after treatment were observed. Results The total effective rate in the combined intervention group was higher than that in the anti-depression group（93.33% vs 66.67%）， and there was an obvious difference after χ2 statistical treatment （P0.05）； the Hamilton depression rating scale score before treatment between the two groups was similar， and there was no obvious difference after t statistical treatment（P0.05）； the Hamilton depression rating scale score in the combined intervention group after treatment was improved more obviously than that in the anti-depression group， and there was an obvious difference after t statistical treatment（P0.05）. Conclusion The effect of paroxetine and amisulpride in treatment of depressive episode with schizophrenic symptoms is definite， and it can effectively improve the depression symptoms of patients， and the medicatio