中药复方对脾气虚ar大鼠鼻黏膜il-2β1-defensinmrna及血清ige表达量的影响-effects of chinese herbal compound on il - 2β 1 - defensin mrna and serum ige expression in nasal mucosa of qi deficiency ar rats.docxVIP

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中药复方对脾气虚ar大鼠鼻黏膜il-2β1-defensinmrna及血清ige表达量的影响-effects of chinese herbal compound on il - 2β 1 - defensin mrna and serum ige expression in nasal mucosa of qi deficiency ar rats.docx

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中药复方对脾气虚ar大鼠鼻黏膜il-2β1-defensinmrna及血清ige表达量的影响-effects of chinese herbal compound on il - 2β 1 - defensin mrna and serum ige expression in nasal mucosa of qi deficiency ar rats

成都中医药大学成都中医药大学 2007 级硕士论文 traditional Chinese medicine and western medicine group and the treatment group compared with the corresponding nasal score was no difference (p 0.05).Serum IgE: Spleen AR group and the AR groups compared with the control group there was significant difference (p0.01).Spleen AR group compared with the AR group significant difference (p0.05); the treatment group compared with the AR group significant difference (p0.01); compared with the control group no significant difference (P0.05) IL - 2 mRNA expression: Spleen AR group and the AR groups compared with the control group there was significant difference (p0.01). Spleen AR group compared with the AR group significant difference (p0.05); the treatment group compared with the AR group significant difference (p0.01), compared with the control group no significant difference (P0.05). β1-Defensin mRNA expression: Spleen AR group and the AR groups compared with the control group there was significant difference (p 0.01).Spleen AR group compared with the AR group significant difference (p0.05); the treatment group compared with the AR group significant difference (p 0.01), compared with the control group no significant difference (P0.05). Conclusion: The spleen deficiency can aggravate nasal symptoms of AR rats. Chinese medicine can significantly improve the nasal mucosa pathological response; and through multi-level, multi-angle on the regulation of cytokine mRNA expression, can play a very good preventive effect. Key words spleen-deficiency allergic rhinitis β1-Defensin IL-2 IgE 42 42 声明硕士学位论文中药复方对脾气虚 AR 大鼠鼻黏膜 IL-2，β1-Defensin mRNA 及血清 IgE 表达量的影响是本人在成都中医药大学攻读硕士学位期间在导师指导下完成的，该论文涉及的有关知识产权归成都中医药大学所有。有关该学位论文成果的开发、转让、论文发表等，均需征得导师和成都中医药大学同意。导师签名：硕士生签名：年月日 PAGE PAGE 2 1.引言变应性鼻炎(Allergic Rhinitis AR)即过敏性鼻炎，是耳鼻喉科的常见病，其发病率较高。变应性鼻炎常伴支气管哮喘，78%的支气管哮喘患者有变应性鼻炎，而 38%的过敏性鼻炎患者也同时患有哮喘[1]，且病程反复，难以治愈，给患者日常工作、生活带来很大痛苦，是中西医工作者都感颇为棘手的问题。数十年的研究基本上阐明了 AR 属于 I 性型变态反应，是鼻黏膜慢性炎性反应性疾病，