恩替卡韦联合肝动脉化疗栓塞术治疗乙肝相关性肝癌临床效果Meta分析.docVIP

恩替卡韦联合肝动脉化疗栓塞术治疗乙肝相关性肝癌临床效果Meta分析 　　[摘要] 目的 系?y评价恩替卡韦联合肝动脉化疗栓塞术（TACE）治疗乙肝相关性肝癌临床效果。 方法 检索中国知网（CNKI）、万方、维普、Pubmed、The Cochrane Library、Embase数据库，检索年限为数据库建库至2017年4月，纳入恩替卡韦联合TACE治疗乙肝相关性肝癌的临床随机对照试验（RCTs），采用Jadad评分法进行文献质量评价，运用RevMan 5.2软件进行Meta分析。 结果 共检索出275篇文献，通过筛查最终纳入文献10篇，共844例患者被纳入Meta分析。Meta分析结果显示：恩替卡韦联合TACE治疗乙肝相关性肝癌患者在近期临床疗效（OR=2.47，95%CI：1.54～3.95，P=0.0002），谷丙转氨酶改善情况（OR=-34.23，95%CI：-46.24～-22.21，P0.00001），HBV DNA定量改善情况（OR=-2.91，95%CI：-4.16～-1.67，P0.00001），甲胎蛋白改善情况（OR=-33.86，95%CI：-37.91～-29.82，P0.00001）优于单纯TACE治疗，而两组患者1年生存率（OR=1.94，95%CI：0.89～4.22，P=0.09）差异无统计学意义。 结论 恩替卡韦联合TACE治疗乙肝相关性肝癌患者效果优于单纯TACE治疗，值得临床推荐应用。 　　[关键词] 恩替卡韦；乙肝；肝癌；肝动脉化疗栓塞术；Meta分析 　　[中图分类号] R73 [文献标识码] A [文章编号] 1673-7210（2017）10（b）-0093-05 　　Meta analysis of the clinical efficacy of antiviral combined with TACE in the treatment of hepatitis B virus associated hepatocellular cancer 　　CHEN Huihua WEN Lingbo LI Jian′an JIA Yanhua 　　Department of Oncology， the Second Affiliated Hospital of Guangxi University of Science and Technology， Guangxi Zhuang Autonomous Region， Liuzhou 545006， China 　　[Abstract] Objective To evaluate the clinical efficacy of antiviral combined with transarterial chemoembolization （TACE） in the treatment of hepatitis B virus associated hepatocellular cancer. Methods The following databases such as CNKI， Wanfang Date， VIP， PubMed， The Cochrane Library， Embase were retrieved from the time of the database established to April 30， 2017.Randomized controlled clinical trials （RCTs） that antiviral combined with transarterial chemoembolization in the treatment of hepatitis B virus associated hepatocellular cancer were included， the Jadad score method was used to carryout quality assessment. Meta-analysis was conducted by RevMan 5.2 software. Results A total of 275 papers were searched. Finally 10 references， 844 patients were included in the Meta analysis. Meta analysis results showed that the Antiviral combined with TACE in the treatment of patients with hepatitis B related hepat