手术和非手术两种治疗方式在颅内多发高级别胶质瘤应用探讨.docVIP

手术和非手术两种治疗方式在颅内多发高级别胶质瘤应用探讨 　　【摘要】 目的：研究手术和非手术两种治疗方式在颅内多发高级别胶质瘤治疗中的应用效果。方法：回顾性分析2009年1月-2013年1月于本院神经外科住院治疗的52例颅内多发高级别胶质瘤患者的临床资料，根据患者治疗方式不同，分为A组（即手术组，37例）和B组（即非手术组，15例）。比较两组患者的手术情况、生存期及早期并发症发生情况。结果：两组患者的病理学资料和影像学资料比较差异均无统计学意义（P0.05）。患者出院后均给予为期1～24个月的随访，所有患者均复发死亡，随访期间无脱失病例。A组患者生存期显著长于B组患者，差异有统计学意义（P0.05）。A组患者术后3例出现严重脑水肿，2例出现颅内感染，2例出现肢体活动障碍，2例出现精神障碍。B组患者在活检术后未见明显并发症发生。A组患者的早期并发症发生率为24.3%（9/37），显著高于B组的0，差异有统计学意义（P0.05）。结论：通过手术切除治疗颅内多发高级别胶质瘤可显著延长患者生存期，应在临床推广应用，但对于一些年龄较大、身体素质较差的患者可能不能耐受手术者，仍应慎重选择。 　　【关键词】 多发高级别胶质瘤； 手术治疗； 生存期 　　中图分类号 R739.41 文献标识码 A 文章编号 1674-6805（2016）16-0011-02 　　【Abstract】 Objective：To study the effect of the application of surgical and nonsurgical in treatment of multiple intracranial high-grade gliomas.Method：The clinical data of 52 patients with multiple intracranial high-grade gliomas hospitalized in our hospital neurosurgery from January 2009 to January 2013 were retrospective analyzed，according to the different therapies，they were divided into group A（the surgery group，37 cases） and group B（the non-surgery group，15 cases）.The surgery condition，survival time and the incidence of early complications between the two groups were compared.Result：The pathological and radiographic data between the two groups showed no significant difference（P0.05）.After hospital discharge，patients were followed up for a period of 1 to 24 months，all patients relapsed and dead without any loss of cases.The survival time in group A was significantly longer than that in group B，the difference was statistically significant（P0.05）.Patients in group A occurred 3 cases of severe cerebral edema，2 cases of intracranial infection，2 cases of limb movement disorder occurs， 2 cases of mental disorders.Group B patients’ biopsy showed no postoperative complications.The early complications occurred in group A was 24.3%（9/37），significantly higher than that in group B，the difference was statistically significant（P0.05）.Conclusion：Surgical resection of multiple intracranial high-grade