慢性乙型肝炎患者免疫球蛋白检验临床研究.docVIP

慢性乙型肝炎患者免疫球蛋白检验临床研究 　　[摘要] 目的 探?慢性乙型肝炎患者检验免疫球蛋白（Ig）的临床价值。方法 随机选取2015年1月―2017年1月该院收治的100例慢性乙型肝炎患者为实验组，另择取同期100名健康志愿者为对照组。于清晨空腹采集两组静脉血液样本，检验血清IgA、IgG、IgM水平，对比观察检验结果。依据肝功能损伤程度将实验组分为一般肝炎患者和重型肝炎患者，予以实验组慢性乙型肝炎综合治疗，对比观察不同病情及预后患者的血清IgA、IgG、IgM检验结果。结果 实验组IgA（2.61±0.35）g/L，IgG（15.52±3.14）g/L，IgM（2.72±0.63）g/L，各项指标均高于对照组，比较差异有统计学意义（P0.05）。实验组重型患者IgA（2.89±0.38）g/L，IgG（16.93±3.23）g/L，IgM（2.90±0.62）g/L，各项指标均高于一般患者，比较差异有统计学意义（P0.05）。经治疗，实验组慢性乙型肝炎改善患者IgA（2.30±0.31）g/L，IgG（13.31±2.97）g/L，IgM（2.45±0.60）g/L，各项指标均低于恶化患者，比较差异有统计学意义（P0.05）。结论 血清免疫球蛋白可用于诊断慢性乙型肝炎的发生、判断慢性乙型肝炎的病情进展及治疗预后评估，值得临床推广使用。 　　[关键词] 慢性乙型肝炎；免疫球蛋白；检验价值 　　[中图分类号] R446 [文献标识码] A [文章编号] 1674-0742（2017）11（a）-0026-03 　　[Abstract] Objective To study the clinical value of immunoglobulin test of patients with chronic hepatitis B. Methods 100 cases of patients with chronic hepatitis B in our hospital from January 2015 to January 2017 were Random selected as the experimental group， while 100 cases of healthy volunteers at the same period were selected as the control group， and the vein blood samples of the two groups were collected in the morning at fasting， and the serum IgA， IgG， IgM levels of patients were tested and the test results were compared and observed and the experimental group was divided into the general hepatitis group and severe hepatitis group according to the liver function injury degree， and the experimental group were given the chronic hepatitis B comprehensive therapy， and the serum IgA， IgG， IgM test results of patients of different disease conditions and prognosis were compared and observed. Results The IgA， IgG， IgM levels in the experimental group were respectively （2.61±0.35），（15.52±3.14），（2.72±0.63）g/L， and various indexes were higher than those in the control group， and the differences were statistically significant（P 　　[Key words] Chronic hepatitis B； Immunoglobulin； Test value 　　慢性乙型肝炎指乙肝病毒检测阳性、临床有慢性炎症表现且病程超过6个月的肝炎，为我国最常见慢性传染病之一，是临床研究已经证实的肝硬化、肝癌高危因素，严重危害患者及人群健康，故其预防及控制一直以来备受卫生组织重视[1]。慢性乙型肝炎临床治