拜新同联合琥珀酸美托洛尔缓释片治疗顽固性高血压临床疗效观察.docVIP

拜新同联合琥珀酸美托洛尔缓释片治疗顽固性高血压临床疗效观察 　　【摘要】 目的 探?硝苯地平控释片（拜新同）联合琥珀酸美托洛尔缓释片治疗顽固性高血压的临床效果。方法 120例顽固性高血压患者， 随机分为实验组及对照组， 各60例。实验组给予拜新同联合琥珀酸美托洛尔缓释片治疗， 对照组单纯给予拜新同治疗。比较两组患者的降压治疗效果、不良反应发生情况及治疗前后的血压变化情况。结果 治疗8周后， 实验组总有效率为90.0%， 明显高于对照组的68.3%， 差异具有统计学意义（P0.05）；治疗8周后， 实验组收缩压及舒张压均明显低于对照组， 差异具有统计学意义（P0.05）。结论 拜新同联合琥珀酸美托洛尔缓释片治疗顽固性高血压， 具有良好的临床效果， 且不良反应发生率低， 安全性好， 值得临床应用。 　　【关键词】 硝苯地平控释片；琥珀酸美托洛尔缓释片；顽固性高血压；临床疗效 　　DOI：10.14163/j.cnki.11-5547/r.2018.04.001 　　Observation on clinical efficacy of adalat combined with metoprolol succinate sustained-release tablets in the treatment of refractory hypertension JIANG Dan-yu. Shenyang Shenhe District People’s Hospital， Shenyang 110001， China 　　【Abstract】 Objective To discuss the clinical effect of nifedipine controlled release tablets （adalat）combined with metoprolol succinate sustained-release tablets in the treatment of refractory hypertension. Methods A total of 120 refractory hypertension patients were randomly divided into experimental group and control group， with 60 cases in each group. The experimental group received adalat combined with metoprolol succinate sustained-release tablets for treatment， and the control group received adalat for treatment. The effect of antihypertensive treatment， occurrence of adverse reaction and the change of blood pressure before and after treatment were compared between the two groups. Results After 8 weeks of treatment， the experimental group had obviously higher total effective rate as 90.0% than 68.3% in the control group， and the difference was statistically significant （P0.05）. After 8 weeks of treatment， the experimental group had obviously lower systolic blood pressure and diastolic blood pressure than the control group， and the difference was statistically significant （P0.05）. Conclusion Combination of adalat and metoprolol succinate sustained-release tablets shows excellent clinical effect in the treatment of refractory hypertension with low incidence of adverse reactions and high safety. It is