探讨抗生素降阶梯治疗小儿重症肺炎临床疗效及安全性.docVIP

探讨抗生素降阶梯治疗小儿重症肺炎临床疗效及安全性 　　[摘要] 目的 探讨抗生素降阶梯治疗小儿重症肺炎的临床疗效与安全性。方法 方便筛选2015年1月―2016年1月该院收治的小儿重症肺炎患儿96例，作为研究对象。采用随机数表法将所有患儿分为观察组与对照组，每组48例，其中对照组患儿接受常规抗生素治疗，观察组患儿采用抗生素降阶梯治疗，比较两组患儿治疗效果以及抗生素应用时间、感染控制时间、住院时间。结果 观察组患儿平均抗生素应用时间（18.9±5.2）d、感染控制时间（10.5±3.8）d、住院时间（14.9±5.2）d明显低于对照组平均抗生素应用时间（24.3±6.1）d、感染控制时间（17.2±2.9）d、住院时间（19.8±6.9）d，P0.05，差异具有统计学意义；观察组患儿治疗后总有效率93.75%明显高于对照组77.08%，P0.05，差异具有统计学意义；两组患儿均无严重不良反应发生。结论 抗生素降阶梯治疗小儿重症肺炎可有效提升其临床治疗效果，并且感染控制时间、住院时间较短，无严重不良反应发生，具有临床应用及推广价值。 　　[关键词] 抗生素降阶梯治疗；小儿重症肺炎；临床疗效；安全性 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-0742（2016）09（b）-0134-03 　　[Abstract] Objective Of antibiotics reduced the clinical efficacy and safety of the ladder for treatment of severe pneumonia in children. Methods Convenient screening January 2015 to January 2016 in our hospital pediatric patients with severe pneumonia in 96 cases， as the research object. The random number table method all patients were divided into observation group and control group， 48 cases in each group， among patients in the control group received conventional antibiotic therapy， observation group were treated with antibiotic de escalation therapy， compared two groups of children with the treatment effect and the use of antibiotics in time， infection control time， hospitalization time. Results In the observation group with the mean of antibiotic hormone application time （18.9±5.2）d infection Control time （10.5±3.8）d， length of hospital stay （14.9±5.2）d was significantly lower than that in the control group， the average use of antibiotics in time （24.3 ±6.1）d， time of infection control （17.2±2.9）d， length of hospital stay （19.8±6.9）d， P 0.05， the difference is statistically significant； the total of the treatment of children in the observation group is obviously higher than that of the control group 77.08% efficiency rate was 93.75%， P 0.05， the difference is statistically significant； two groups of children had no serious adverse reactions. Conclusion Antibiotics drop step in the treatment of c