探究左西孟旦对慢性心功能衰竭患者T细胞功能影响.docVIP

探究左西孟旦对慢性心功能衰竭患者T细胞功能影响 　　【摘要】 目的 探究左西孟旦对慢性心功能衰竭患者T细胞功能的影响。方法 114例慢性心功能衰竭患者， 根据随机数字表法分为对照组和观察组， 每组57例。对照组患者给予常规抗心功能衰竭药物治疗， 观察组患者在对照组基础上给予左西孟旦治疗， 比较两组临床疗效、T细胞功能及血清指标、不良反应。结果 观察组总有效率为89.47%， 明显高于对照组的75.44%， 差异具有统计学意义（P0.05）。治疗后两组患者CD4+、CD8+、CD4+/CD8+水平均明显优于治疗前， 且观察组优于对照组， 差异具有统计学意义（P0.05）。治疗后两组患者血浆N末端脑钠肽前体（NT-proBNP）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白T（cTnT）均明显低于治疗前， 且观察组低于对照组， 差异具有统计学意义（P0.05）。两组均未见明显不良反应。结论 左西孟旦能提高慢性心功能衰竭患者临床治疗效果， 改善T细胞功能和血清指标， 减轻心肌损伤， 安全性高。 　　【关键词】 慢性心功能衰竭；左西孟旦；T细胞功能 　　DOI：10.14163/j.cnki.11-5547/r.2017.34.001 　　Investigation on the effect of levosimendan on T cell function in patients with chronic heart failure HU Yong-yi， FENG Li. Department of Internal Medicine-Cardiovascular， People’s Hospital， Zhongshan 528400， China 　　【Abstract】 Objective To investigate the effect of levosimendan on T cell function in patients with chronic heart failure. Methods A total of 114 patients with chronic heart failure were divided by random number table method into control group and observation group， with 57 cases in each group. The control group was treated with conventional antiarrhythmic drugs， and the observation group was treated with levosimendan on the basis of the control group. Comparison were made on clinical efficacy， T cell function， serum markers and adverse reactions between two groups. Results The observation group had obviously higher total effective rate as 89.47% than 75.44% in the control group， and the difference was statistically significant （P0.05）. After treatment， both groups had obviously better CD4+， CD8+ and CD4+/CD8+ level than before treatment， and the observation group was better than the control group. Their difference was statistically significant （P0.05）. After treatment， both groups had obviously lower plasma N-terminal pro brain natriuretic peptide （NT-proBNP）， creatine kinase isoenzyme （CK-MB） and cardiac troponin T （cTnT） than before treatment， and the observation group was lower than the control group. Their difference was statistica