探讨阿法骨化醇治疗和预防100例老年性骨质疏松疗效及分析.docVIP

探讨阿法骨化醇治疗和预防100例老年性骨质疏松疗效及分析 　　摘 要 目的：探讨阿法骨化醇治疗和预防老年性骨质疏松的疗效及预防措施。方法：200例老年原发性骨质疏松症患者随机分成两组，治疗组和对照组各100例。对照组患者每天口服钙剂，治疗组在此基础上加服阿法骨化醇。结果：两组患者治疗前骨密度比较差异无统计学意义（P0.05）。治疗后两组指标都有明显升高，但治疗组骨密度较对照组增加更明显，有统计学意义（P0.05）。治疗组疼痛改善率78%，对照组为35%，治疗组明显好于对照组（P0.05）。结论：阿法骨化醇治疗老年性骨质疏松症能够有效提高骨密度，缓解疼痛。 　　关键词 阿法骨化醇 老年骨质疏松症 骨密度 　　中图分类号：R977； R969.4 文献标识码：B 文章编号：1006-1533（2013）09-0021-03 　　Analysis of the therapeutic effect of alfacalcidol 　　on 100 cases of patients with senile osteoporosis 　　HUANG Xiaopeng1， MENG Jian2 　　（1. Department of Orthopaedics，Yangsi Hospital， Shanghai 200126， China； 　　2. Endocrine Metabolism Ward， Shidong Hospital， Shanghai 200438， China） 　　ABSTRACT Objective： To explore the therapeutic efficacy of alfacalcidol on senile osteoporosis and to discuss its preventive measures.Methods： Two hundred elderly patients with primary osteoporosis were divided into two groups （each n=100）.Patients in the control group were treated with basic daily oral calcium while alfacalcidol therapy was additinally given in the treatment group besides the basic treatment.Results： Before the treatment， no statistically significant difference was found between the two groups （P0.05）.After the treatment， the indicators of patients in the two groups were significantly increased， however bone mineral density （BMD） at the femoral neck and L 2-4 were significantly higher in the treatment group than in the control group （P0.05）.The total response rate of pain improvement was 78.0%in the treatment group and 35.0%in the control group， and the treatment group was superior to the control group （P0.05）. Conclusion： Alfacalcidol for the treatment of senile osteoporosis can effectively improve bone mineral density and relieve the pain. 　　KEY WORDS alfacalcidol； senile osteoporosis； bone mineral density 　　随着社会的经济发展与医疗技术进步及人口老龄化的到来，人们越来越认识到骨质疏松症发生的普遍性及严重性。骨质疏松症主要表现为骨质的有机成分生成不足，继发钙盐减少及骨组织细微结构的破坏，继而造成临床骨折发生率的增加。阿法骨化醇能在体内起调节钙磷的平衡作用，增加钙磷在肠道的吸收，降低血浆中甲状旁腺激素水平以及改善妇女绝经和激素类药物引起的骨质疏松。我们选择在门诊治疗原发性老年骨质疏松症的患