腹腔镜联合促性腺激素释放激素激动剂(GnRH―a)治疗子宫内膜异位症的疗效分析.docVIP

腹腔镜联合促性腺激素释放激素激动剂(GnRH―a)治疗子宫内膜异位症的疗效分析 　　【摘要】目的：比较腹腔镜术和腹腔镜术联合促性腺激素释放激素激动剂（GnRH-a）治疗子宫内膜异位症的近期疗效和远期疗效。方法：根据患者自愿，将120例子宫内膜异位症患者分为观察组65例和对照组55例。对照组采用腹腔镜术治疗，观察组采用腹腔镜联合GnRH-a治疗。在治疗3个月后进行近期疗效评价。所有患者随访2年，记录复发情况和妊娠情况。结果：经治疗3个月后，观察组痊愈、有效、无效例数分别有38例（5846%）、22例（3385%）、5例（769%），治疗有效率为9231%，显著高于对照组7455%的治疗有效率（χ2=7053，P005）。观察组复发7例，复发率为1077%，显著低于对照组（χ2=6455，P005）。观察组妊娠31例，妊娠率8158%，显著高于对照组（χ2=5677，P005）。结论：相比于单纯腹腔镜手术治疗方案，联合疗法具有更好的近期和远期疗效，值得临床推广。 　　【关键词】子宫内膜内异症；腹腔镜术；促性腺激素释放激素激动剂；疗效评价 　　The curative effect oflaparoscopy combined with GnRH-a in the treatment of endometriosisCHENG Shan1， MA Jianfang2. 1. Department of Obstetrics and Gynecology， The 903 Hospital in Jiangyou City， Mianyang 621700， China； 2. Department of Gynecology， Xining City First People’s Hospital， Xining 810000， China 　　【Abstract】Objectives： To compare the short-term and long-term therapeutic effect of laparoscopy and laparoscopic surgery combined with GnRH-a in the treatment of endometriosis. Methods： 120 patients with endometriosis were divided into the observation group （65 cases） and control group （55 cases） according to the patients’ willing. The control group were treated by laparoscopic while the observation group were treated by laparoscopic combined with GnRH-a therapy. Short term efficacies were evaluated after 3 months. All patients were followed up for 2 years and the recurrence and pregnancy were recorded. Results： The cured， effective and ineffective cases in the observation group were 38 （58.46%）， 22 （33.85%）， 5 （7.69%） respectively， an effective rate of treatment being 92.31%， which was significantly higher than the control group （χ2=7.053， P005）. The recurrence rate in the following 2 years of the observation group was 1077%， which was significantly lower than the control group （χ2=6.455， P005）. The pregnancy rate of the observation group was 81.53%， which was significantly higher than that of the control group （χ2=5.811， P005）. Conclusion： Compared with laparoscopic surgical treatment， lapar