新生儿窒息与血乳酸和心肌酶关系研究.docVIP

新生儿窒息与血乳酸和心肌酶关系研究 　　【摘要】 目的：探讨新生儿窒息心肌酶水平和血乳酸（LAC）的关系，为新生儿窒息早期诊断提供新的依据。方法：将入选的新生儿归为窒息组（n=75，依据Apgar评分分为轻、重度窒息两组，轻度窒息组46例，重度窒息组29例）和对照组（n=31），对两组新生儿出生后1 h内谷草转氨酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶同工酶（CK-MB）、肌酸激酶（CK）、血乳酸进行测定和比较分析。结果：轻度窒息组和重度窒息组新生儿血乳酸和心肌酶水平明显升高，与对照组比较差异均有统计学意义（P0.05）。结论：新生儿窒息缺氧可导致心肌损伤，血乳酸和心肌酶检测可作为判断新生儿窒息及严重程度早期诊断的重要指标。 　　【关键词】 新生儿窒息； 血乳酸； 心肌酶 　　中图分类号 R722.12 文献标识码 B 文章编号 1674-6805（2015）7-0073-02 　　Study of Relationship between Blood Lactate and Myocardial Enzymes of Neonatal Asphyxia/HE Xiao-ying，CHEN Zhao-yu.//Chinese and Foreign Medical Research，2015，13（7）：73-74 　　【Abstract】 Objective：To explore the relationship between blood lactate（LAC） and myocardial enzymes levels of neonatal asphyxia，and to provide a new basis for the early diagnosis of neonatal asphyxia.Method：The selected newborns were divided into two groups，31 cases in the control group，75 cases in the asphyxia group（according to Apgar score，the asphyxia group was divided into mild and severe asphyxia group，46 cases in mild asphyxia group，29 cases in severe asphyxia group）.The levels of blood LAC and aspartate aminotransferase（AST），lactate dehydrogenase（LDH），creatine kinase（CK），creatine kinase isoenzyme（CK-MB） of two groups were measured at 1 hour after birth respectively，and then made a comparative analysis.Result：The blood lactate and myocardial enzyme levels of mild and severe neonatal asphyxia were significantly higher than those of the control group，there were significant differences（P0.05）.Conclusion：Neonatal asphyxia can lead to myocardial injury，detection of blood lactic acid and myocardial enzyme levels can be used as an important index for the early diagnosis of neonata asphyxia and the severity of judgment. 　　【Key words】 Neonatal asphyxia； Blood lactate； Myocardial enzymes 　　First-author’s address：Foshan Material and Children Hospital， Foshan 528000， China 　　doi：10.14033/j.cnki.cfmr.2015.07.035 　　新生儿窒息（asphyxia asphyxia）定义为在产前、产时、产后出现各类原因令新生儿无法正常呼吸，导致缺氧，使全身多脏器发生损害[1]。它为围生期新生儿比较多发的症状及其重要