放疗同步联合化疗对照单纯化疗治疗局部晚期非小细胞肺癌临床研究.docVIP

放疗同步联合化疗对照单纯化疗治疗局部晚期非小细胞肺癌临床研究 　　【摘要】 目的 研究观察放疗同步联合化疗对照单纯化疗治疗局部晚期非小细胞肺癌疗效。方法 CT、病理学证实的局部晚期非小细胞肺癌62例，随机分成同步放化疗组和单纯化疗组。放疗均采用三维适形放疗，两组化疗方案均采用紫杉醇联合卡铂，共二个周期。治疗结束后比较两组疗效及不良反应。结果同步放化疗组和单纯化疗组的有效率分别为64.5%和38.7%（P=0.042），一年生存率分别为58.1%和29.0%（P=0.021），两组间疗效与一年生存率均存在显著统计学差异。两组不良反应主要表现为白细胞减少、血小板减少、肝功能异常、心脏毒性、恶性呕吐等，不良反应均无统计学差异（Pgt;0.05）。结论同步化放疗能明显提高治疗局部晚期非小细胞肺癌有效率和近期生存率，且与单纯化疗相比并不增加不良反应。 　　【关键词】局部晚期非小细胞肺癌;同步放化疗;化学治疗 Clinical study of radiotherapy combined with concurrent chemotherapy compared with simple chemotherapy for locally advanced non-small cell lung cancer Xie-Jun1，Liu De-gan2，Xu Wen-jing2，Zhai Chen-tong2 （1Department of Oncology， Xinghua Third Peoples Hospital， Jiangsu Xinghua 225700，china;2 Department of Oncology ，Xinghua Peoples Hospital， Jiangsu Xinghua 225700，china） 　　[Abstract] Objective To study the effect of concurrent chemoradiotherapy compared with simple radiotherapy for locally advanced non-mall cell lung cancer.Methods 62 cases of non-small cell lung cancer confirmed by CT and pathology w-ere randomly divided into concurrent chemoradiotherapy group and simple chemot-herapy group. Radiotherapy were treated by three-dimensional conformal radioth-erapy， The two groups were treated for two cycles with paclitaxel and carbopla-tin.Result The effective rate of concurrent chemoradiotherapy group and simple chemotherapy group were respectively 64.5% and 38.7% （P=0.042）. One-year survi-val rates were respectively 58.1% and 29% （P=0.021）. The effective rate and one-year survival rate of the two groups were statistically significant difference. Adverse reactionsof the two groups mainly for white blood cell reduced、throm-bocytopenia、liver dysfunction、cardiac toxicity、nausea and vomiting et al.Th-ere were no significant differences in adverse reactions （Pgt;0.05）. Conclusions Concurrent chemoradiotherapy for locally advanced non-small cell lung cancer c-an significantly improve the curative effect and one-year survival rate， but d- 　　on’t increase the adverse rea-ction