有氧运动联合膳食干预对2糖尿病大鼠骨骼肌胰岛素受体亲和力影响.docVIP

有氧运动联合膳食干预对2糖尿病大鼠骨骼肌胰岛素受体亲和力影响 　　摘 要: 目的:研究有氧运动和膳食控制对2型糖尿病大鼠骨骼肌胰岛素受体亲和力的影响。方法:6 2只雄性大鼠,随机分为正常对照组(C组),DM对照组(DM)、DM+运动锻炼组(DME )、DM+膳食控制组(DMD)、DM+运动锻炼+膳食控制组(DMED),用受体放射性配基结 合分析法(RBA)测定各组大鼠骨骼肌胰岛素受体亲和力。结果表明:1) 与正常大鼠比较 ,糖尿病大鼠骨骼肌胰岛素高、低亲和力受体亲和力常数KD1、KD2都有非常显著性增加 (P0.05),KD2有非常显著性下降(P0.05),且运动和膳食控制没有交互作用(P0.05)。结论:糖尿病大 鼠胰岛素受体亲和力出现了显著性下降,有氧运动能够增强糖尿病大鼠胰岛素受体结合力, 但膳食控制对其作用不明显,且与运动没有交互作用。说明胰岛素受体在糖尿病的发病机制 及运动干预过程中都起到了重要的作用。 　　关键词:糖尿病;有氧运动;膳食控制;胰岛素受体 　　中图分类号:G804.7 　　文献标识码:A 　　文章编号 :1007-3612(2010)02-0053-04 　　 　　Effects of Aerobic Exercise and Dietary Control on the Affinity 　　of Insulin Receptor of ?Skeletal Muscles in Diabetic Rats 　　LIU Xia?1,JIN Qi?guan?1,YE Ming?2 　　(1.Physical Education College, Yangzhou University,Yangzhou 22 5009,Jiangsu China; ?2. Department of sport physiology, Capital institut e of physical education,Beijing 100088,China) 　　Abstract: The objective of the thesis is to research the effects of aerobic exer cise and dietary control on the affinity of insulin receptor of skeletal muscles of diabetic rats. Method:62 male SD rats were randomly divided into fived grou ps:control group(C), diabetes group(DM), diabetes and exercise group(DME), diabe tes and dietary control group(DMD),diabetes and exercise and dietary control gro up(DMED), We measured the affinity of insulin receptor of skeletal muscles in al l rats by RBA. Result:1)Compared with the controll group, the KD1 and KD2 o f skeletal muscles in diabetic rats were significantly increased(P0.05),and aerobic exerci se and dietary control had no significant interaction on it(P0.05).Conclu sion: The affinity of insulin receptor of skeletal muscles in diabetic Rats was significantly decreased, aerobic exercise training could increase the affinity o f insulin receptor of skeletal muscles in diabetic Rats, but dietary control had no effect on it,and aerobic exercise and dietary control had no significant in teraction on it.This research indicated that insulin receptor played an very im portant role