替加环素联合头孢哌酮舒巴坦治疗老年泛耐药鲍曼不动杆菌重症肺炎效果分析.docVIP

替加环素联合头孢哌酮舒巴坦治疗老年泛耐药鲍曼不动杆菌重症肺炎效果分析 　　[摘要]目的 了解替加环素联合头孢哌酮/舒巴坦治疗老年泛耐药鲍曼不动杆菌重症肺炎患者的效果。方法 将2013年6月～2016年6月我院干部综合科与呼吸科收治的100例老年泛耐药鲍曼不动杆菌肺炎患者作为研究对象，随机分为对照组和观察组，各50例。对照组给予头孢哌酮/舒巴坦治疗，观察组给予替加环素联合头孢哌酮/舒巴坦治疗，比较两组的临床疗效。结果 观察组的体温、??音、C-反应蛋白、白细胞、胸片检查改善时间短于对照组，脱机成功率及总有效率高于对照组，差异有统计学意义（P0.05）。观察组的细菌清除率及再感染率优于对照组，不良反应发生率低于对照组，差异有统计学意义（P0.05）。结论 对于老年泛耐药鲍曼不动杆菌重症肺炎患者，给予替加环素联合头孢哌酮/舒巴坦治疗，要比单纯使用一种药物治疗方式效果显著，在安全性等方面相对理想，值得临床推广应用。 　　[关键词]替加环素；头孢哌酮/舒巴坦；鲍曼不动杆菌；老年患者 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-4721（2017）04（c）-0128-04 　　[Abstract]Objective To investigate the efficacy of Tigecycline combined with Cefoperazone/Sulbactam in the treatment of elderly patients with severe pneumonia caused by Acinetobacter baumannii.Methods 100 elderly patients with pneumonia caused by Acinetobacter baumannii were treated in our hospital from June 2013 to June 2016 were selected and randomly divided into the control group and the observation group，50 cases in each group.The control group was treated with Cefoperazone/Sulbactam treatment，the observation group was treated with Tigecycline combined with Cefoperazone/Sulbactam.The clinical efficacy of the two groups was compared.Results The improvement time of body temperature，rales，C- reactive protein，white blood cells and chest radiography in the observation group was shorter than that in control group，the offline success rate and total effective rate of the observation group was higher than that of the control group，with significant difference （P0.05）.The bacterial clearance rate and the reinfection rate in the observation group was better than that in the control group，and the incidence rate of adverse reaction in the observation group was lower than that in the control group，with significant difference （P0.05）.Conclusion For the elderly patients with severe pneumonia caused by Acinetobacter baumannii，Tigecycline combined with Cefoperazone/Sulbactam is more effective than simple use of a drug treatment，with relative ideal in safety，it is worthy of clin