替加环素联合舒巴坦在呼吸机相关性肺炎中应用效果分析.docVIP

替加环素联合舒巴坦在呼吸机相关性肺炎中应用效果分析 　　[摘要] 目的 探讨呼吸机相关性肺炎（VAP）的病原菌分布情况以及替加环素联合舒巴坦在VAP治疗中的应用效果。 方法 选取2012年1月～2014年12月本院收治的120例行机械通气后并发VAP患者作为研究对象，随机分为治疗组和对照组，各60例。治疗组采用替加环素联合舒巴坦静脉滴注，对照组采用美罗培南联合舒巴坦静脉滴注。对其下呼吸道分泌物病原菌进行培养，比较两组的治疗效果及不良反应发生率。 结果 下呼吸道痰液共分离出178株病原菌，其中革兰氏阴性菌（以铜绿假单胞菌、鲍曼不动杆菌为主）与革兰氏性阳性菌（以金黄色葡萄球菌为主）分离率分别占74.16%与19.67%，真菌为6.18%。治疗组的总显效率为73.3%，显著高于对照组的55.5%，差异有统计学意义（P0.05）。 结论 替加环素联合舒巴坦治疗VAP效果显著，值得临床推广应用。 　　[关键词] 呼吸机相关性肺炎；替加环素；舒巴坦；耐药 　　[中图分类号] R563.1+9 [文献标识码] A [文章编号] 1674-4721（2015）06（a）-0144-04 　　Application effect analysis of tigecycline combined with sulbactam in ventilator-associated pneumonia 　　ZHANG Zhan-qiang1 NIU Hui-yan2▲ ZHANG Chai1 LI Rui-xue3 SONG Yan-yin4 ZHANG Li-feng1 ZHU Jiang-bin2 GUO Qing-chun1 GONG Tie-feng1 　　1.Department of Pneumology，Hospital of Zhuozhou City in Hebei Province，Zhuozhou 072750，China；2.Department of Neurology，Hospital of Zhuozhou City in Hebei Province，Zhuozhou 072750，China；3.Department of Physiotherapy，Hospital of Zhuozhou City in Hebei Province，Zhuozhou 072750，China；4.Departmentment of Obstetrics and Gynecology，Hospital of Zhuozhou City in Hebei Province，Zhuozhou 072750，China 　　[Abstract] Objective To explore pathogenic bacteria distribution of ventilator-associated pneumonia（VAP） and the application effect of tigecycline combined with sulbactam in the treatment of VAP. Methods 120 VAP patients with mechanical ventilation from January 2012 to December 2014 in our hospital were selected and randomly divided into the treatment group and the control group，60 cases in each group.The treatment group was treated with intravenous drip of tigecycline combined with sulbactam，the control group was treated with intravenous drip of meropenem with sulbactam.Pathogenic bacteria from secretions of the lower respiratory tract was cultivated，the treatment effect and the incidence of adverse reaction in two groups was compared. Results There were 178 strains of pathogenic bacteria separated from sputum of lower respiratory tract，the separation r