替吉奥联合吉西他滨治疗晚期胰腺癌临床疗效分析.docVIP

替吉奥联合吉西他滨治疗晚期胰腺癌临床疗效分析 　　[摘要] 目的 探讨替吉奥联合吉西他滨治疗晚期胰腺癌的有效性、安全性。 方法 随机选取我院2012年1月～2016年1月晚期胰腺癌82例，随机分为对照组和试验组，对照组40例单独静滴吉西他滨化疗，试验组42例予替吉奥联合吉西他滨化疗。每3个周期复查，评定临床疗效，统计分析两组的临床总有效率、疾病控制率及胃肠道不良反应、骨髓抑制、肾脏和肝脏毒性等发生率。 结果 试验组临床总有效率为 40.5%，疾病控制率为71.4%，与对照组的30.0%和55.0%比较明显高于对照组，但差异无显著性。两组不良反应发生率方面比较，试验组骨髓抑制49.9%、胃肠道反应54.7%、肝脏毒性19.0%略高于对照组的42.5%、50.0%、15.0%，但无显著性差异。两组肾脏毒性发生率相近，分别为7.1%和7.5%。 结论 替吉奥联合吉西他滨治疗晚期胰腺癌的临床总有效率、疾病控制率等优于单独静滴吉西他滨化疗，但差异无统计学意义，两者药效、安全性相当，可作为有效治疗晚期胰腺癌的方案之一。 　　[关键词] 替吉奥；吉西他滨；晚期胰腺癌；不良反应 　　[中图分类号] R979.1 [文献标识码] B [文章编号] 1673-9701（2017）28-0058-03 　　[Abstract] Objective To investigate the efficacy and safety of Tegafur combined with gemcitabine in advanced pancreatic cancer. Methods 82 patients with advanced pancreatic cancer from January 2012 to January 2016 were randomly selected. They were randomly divided into two groups， namely the control group and the study group. The control group of 40 patients were given intravenous infusion of gemcitabine alone for chemotherapy， and the experimental group of 42 patients were given Tegafur combined with gemcitabine for chemotherapy. Regular review was carried out every 3 courses， and the clinical efficacy was evaluated. Statistical analysis was carried out for their respective clinical total efficiency， disease control rate and incidence rate of gastrointestinal adverse reactions， myelosuppression， and kidney and liver toxicity. Results The total clinical effective rate was 40.5%， and the disease control rate was 71.4%. Compared with that of 30.0% and 55.0% in the control group， the rate was higher， but the difference was not significant. In terms of the incidence rate of adverse reactions， there was 49.9% of bone marrow suppression， 54.7% of gastrointestinal reaction and 19.0% of liver toxicity in the study group， which were all slightly higher than those in the control group（42.5%， 50.0%， 15.0%）， but there was no significant difference. The incidence rate of renal toxicity was similar in both groups， at 7.1% and 7.5% res