止咳平喘汤治疗支气管哮喘患儿效果及对T淋巴细胞亚群及血清IL―4和IFN―γ影响.docVIP

止咳平喘汤治疗支气管哮喘患儿效果及对T淋巴细胞亚群及血清IL―4和IFN―γ影响 　　[摘要]目的 探?止咳平喘汤治疗支气管哮喘患儿的效果及对T淋巴细胞亚群及血清γ-干扰素（IFN-γ）、白介素-4（IL-4）的影响。方法 选取2012年6月～2016年4月于我院儿科确诊的82例支气管哮喘患儿作为研究对象，随机分为对照组（40例）和观察组（42例）。对照组采用布地奈德福莫特罗粉吸入剂治疗，观察组在对照组的基础上联合使用止咳平喘汤，3个月为1个疗程。比较两组的临床疗效。结果 治疗3个月后，两组患儿的每月哮喘发作次数、上呼吸道感染次数均少于治疗前，喘息症状天数短于治疗前，IL-4水平低于治疗前，INF-γ水平高于治疗前，差异有统计学意义（P0.05）。观察组治疗3个月后的每月哮喘发作次数、上呼吸道感染次数少于对照组治疗后，喘息症状天数短于对照组治疗后，IL-4水平低于对照组治疗后，INF-γ水平高于对照组治疗后，差异有统计学意义（P0.05）。对照组的CD3+、CD4+、CD4+/CD8+ T细胞水平未改善，观察组治疗后的CD3+、CD4+、CD4+/CD8+T细胞水平较治疗前明显升高，差异有统计学意义（P0.05）。观察组的总有效率为92.86%，显著高于对照组的77.50%，差异有统计学意义（P0.05）。结论 止咳平喘汤治疗支气管哮喘效果显著，可更好地改善炎症反应及免疫功能，值得临床推广。 　　[关键词]止咳平喘汤；支气管哮喘；T淋巴细胞亚群；γ-干扰素；白介素-4 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2016）12（c）-0069-04 　　Effect of Zhike Pingchuan Decoction on children with bronchial asthma and its influence on sub-group of T lymphocyte and serum of IL-4 and IFN-γ 　　LIU Yuan-song 　　Maternal and Child Health Hospital in Luojiang District of Quanzhou City，Fujian Province，Quanzhou 362000，China 　　[Abstract]Objective To explore the effect of Zhike Pingchuan Decoction on children with bronchial asthma and its influence on sub-group of T lymphocyte and serum of interferon-γ （IFN-γ） and interleukin-4 （IL-4）.Methods A total of 82 children definitely diagnosed as bronchial asthma in our hospital from June 2012 to April 2016 were selected as research objects.They were randomly divided into control group （n=40） and observation group （n=42）.In the control group，inhalant of Budesonide Formoterol Powder was used，while in the observation group，Zhike Pingchuan Decoction was added on the basis of the control group.The course of treatment was 3 months.The clinical effect in the two groups was compared.Results After 3-month therapy，frequency of asthma attack per month and frequency of upper respiratory infection （URI） were both less than those before treatment，the time of asthma after treatment was shorter，the IL-4 level was lower and the INF-γ level was higher in comparison with those before treatm