桑枝提取物对糖尿病大鼠作用研究.docVIP

桑枝提取物对糖尿病大鼠作用研究 　　【摘要】 目的 研究桑枝提取物对糖尿病大鼠血糖及氧化应激的影响。方法 采用四氧嘧啶复制糖尿病大鼠模型,灌胃给药4周后测定空腹血糖(FPG)、血清超氧化物歧化酶(SOD)活性、血清及肝脏中丙二醛(MDA)水平。结果 桑枝提取物能够明显降低糖尿病大鼠血糖、提高血清SOD活性、降低MDA的含量,与对照组相比,差异有统计学意义(P0.05)。结论 桑枝提取物可降低糖尿病大鼠血糖并能够提高其抗氧化能力。 　　【关键词】桑枝提取物;糖尿病模型;氧化应激 　　 　　Effects of Ramulus mori extractss on Blood Glucose and Oxidative stress in Diabetic Rats 　　 　　XING Dong-jie,LI Guang-yuan,SUN Yong-qing,et al.Department of Western Medicine Education of Shandong Traditional Chinese Medicine college1,Affiliated Hospital ofShandong Traditional Chinese Medicine College2,Shandong 265200,China 　　 　　【Abstract】 Objective To study the effects of Ramulus mori extracts on blood glucose and peroxidation in diabetic rats.Methods Copy diabetic rat model using alloxan,were given medicine for 4 weeks and the levels of blood glucose,serum superoxide dismutase(SOD)activity,malondialdehyde(MDA)were measured.Results Serum SOD of rats in DM group significantly decreased than that of normal control group; serum and MDA in liver and pancreas significantly increased than that of normal control group(P0.01).After treatment by Ramulus mori extracts,blood glucose levels in diabetic rats decreased,serum SOD levels had a greater increase,the content of serum and MDA in liver and pancreas significantly decreased.Compared with the control group,there was a significant difference(P0.05).Conclusion Ramulus mori extracts can reduce blood glucose in diabetic rats and improve their oxidation resistance.This may have positive significance for preventing the occurrence of diabetes and its complications. 　　【Key words】 Ramulus mori extracts;Diabetes model; Oxidative stress 　　 　　? 　　基金项目:山东省中医管理局中医药科技发展计划项目(项目编号:2007-204) 　　作者单位:265200莱阳, 　　山东中医药高等专科学校西医教学部(邢冬杰 李广元 孙永庆 刘玉明 宿世震); 　　山东中医药高等专科学校附属医院检验科(刘玉明) 　　 　　糖尿病是一种以慢性高血糖为特征的代谢性疾病,常并发血管、神经、眼等方面的并发症。许多研究证实,糖尿病及并发症的发生、发展与氧自由基反应增强和氧自由基酶类活性降低有密切关系[1]。桑枝是桑科植物桑的干燥嫩枝,《中华人民共和国药典》记载为祛风湿、利关节的常用药,用于治疗肩臂关节酸痛、麻木。研究认为黄酮类化合物是桑枝中的一种主要功效成分,对人体具有明显的抗溃疡、抗炎、降血糖等功效[2]。但有关其抗氧化方面的报道鲜见,