氟西汀改善脑卒中后抑郁及神经功能缺损患者临床研究.docVIP

氟西汀改善脑卒中后抑郁及神经功能缺损患者临床研究 　　[摘要]目的 分析氟西汀改善脑卒中患者抑郁及神经功能缺损的临床效果。方法 选择2013年6月～2014年6月我院81例脑卒中患者，随机将患者分为观察组（40例）和对照组（41例），两组患者入院后均实施脑血管疾病常规治疗，在此基础上对观察组患者加用氟西汀进行治疗。比较两组患者治疗前后的抑郁改善程度及神经功能缺损情况，观察药物不良反应。结果 两组患者治疗前神经功能缺损及抑郁评分比较，差异无统计学意义（P0.05）。治疗后，观察组抑郁评分明显低于对照组，差异有统计学意义（P0.05）；观察组神经功能缺损评分显著低于对照组，差异有统计学意义（P0.05）。两组患者均未出现严重药物不良反应。结论 氟西汀能够有效缓解脑卒中患者抑郁情绪，改善患者神经功能缺损程度，且临床用药安全可靠，值得推广应用。 　　[关键词]脑卒中；氟西汀；抑郁情绪；神经功能缺损 　　[中图分类号] R743.2 [文献标识码] A [文章编号] 1674-4721（2016）08（a）-0061-03 　　[Abstract]Objective To analyze the clinical effect of fluoxetine in improving depression and neurological function of patients with stroke.Methods From June 2013 to June 2014，81 cases of stroke patients in our hospital were randomly divided into observation group （40 cases） and control group （41 cases），patients in two groups were treated with conventional treatment of cerebral vascular disease，besides patients in the observation group were treated with fluoxetine.The improvement of depression and neurological function were compared between two groups before and after treatment，and adverse drug reactions were observed.Results The scores of depression and neurological function between two groups before treatment were not statistically significant （P0.05）.After treatment，depression score in the observation group was significantly lower than that in the control group，the difference was statistically significant （P0.05）；the neurological function defect score in the observation group was significantly lower than that in the control group （P0.05）.Patients in two groups did not have serious adverse drug reactions.Conclusion Fluoxetine can effectively relieve depression of patients with stroke，improve the degree of neurologic deficits.Clinical medication is safe and reliable and it is worth to clinical promoting and application. 　　[Key words]Stroke；Fluoxetine；Depression；Neurological deficit 　　脑卒中具有高发病率、高致残率、危害性大等特点，老年人是此病高发人群。权威资料显示，部分卒中患者会出现抑郁，卒中后抑郁（post-stroke depression，PSD）是指与卒中相关的临床上以兴趣减退、情绪低落、睡眠障碍、易激怒等为主要