氯吡格雷联合溶栓治疗急性心肌梗死疗效评价.docVIP

氯吡格雷联合溶栓治疗急性心肌梗死疗效评价 　　[摘要] 目的 探讨和研究氯吡格雷联合溶栓治疗急性心肌梗死的临床疗效。方法 选取2012年1月―2013年5月之间该院收治的50例急性心肌梗死患者作为研究对象，根据入院编号进行随机分组，分为观察组和对照组，各25例，对照组单纯采用重组人组织型纤溶酶原激酶衍生物进行溶栓治疗，观察组患者则在溶栓治疗基础上加用氯吡格雷联合治疗，对比两组患者的疗效及心肌酶谱变化。结果 观察组患者总有效率92.0%，显著高于对照组患者的76.0%，差异有统计学意义（P0.05）；治疗前两组患者的肌酸激酶、肌酸激酶同工酶对比差异无统计学意义，治疗后观察组显著低于对照组，差异有统计学意义（P0.05）。 结论 氯吡格雷联合溶栓治疗急性心肌梗死的疗效确切，相较于单纯溶栓治疗更具优势，能够有效降低心肌酶水平，提高疗效，值得在临床上推广和应用。 　　[关键词] 急性心肌梗死；氯吡格雷；重组人组织型纤溶酶原激酶衍生物；溶栓治疗 　　[中图分类号] R [文献标识码] A [文章编号] 1674-0742（2015）01（b）-0114-02 　　Evaluation of curative effect of clopidogrel combined with thrombolytic therapy in acute myocardial infarction 　　WEN Xia HE Tao CHEN Guangyuan CANG Hongyu 　　First aid center of the Inner Mongolia Autonomous Region peoples Hospital，010000，China 　　[Abstract] Objective To investigate the clinical effect of clopidogrel combined with thrombolytic therapy for acute myocardial infarction. Methods the object of study selected 50 cases of patients with acute myocardial infarction between 2012.1～2013.5 in our hospital， were randomly grouped according to the admission number， divided into the observation group and the control group with 25 cases in each group， the control group only with recombinant human tissue type plasminogen kinase derivatives for thrombolytic therapy， patients in the observation group was added based on the thrombolytic therapy with clopidogrel treatment， efficacy and myocardial enzyme changes were compared between the two groups of spectra. Results the patients in the observation group the total efficiency of 92%， significantly higher than the control group of 76% patients， with significant difference（P 0.05）； in two groups before treatment in patients with creatine kinase， creatine kinase isoenzyme compared no significant difference after treatment， the observation group was significantly lower than the control group， the difference was statistically significant（P 0.05）. Conclusion the curative effect of clopidogrel combined with thrombolytic therapy for acute myocardi