氯吡格雷联合瑞舒伐他汀治疗不稳定型心绞痛临床疗效观察.docVIP

氯吡格雷联合瑞舒伐他汀治疗不稳定型心绞痛临床疗效观察 　　[摘要] 目的 评价氯吡格雷联合瑞舒伐他汀治疗不稳定型心绞痛的临床疗效。 方法 选择2012年12月～2014年12月100例不稳定心绞痛患者作为研究对象，其中应用氯吡格雷联合瑞舒伐他汀治疗的50例不稳定心绞痛患者设为观察组，单纯应用氯吡格雷治疗的50例不稳定心绞痛患者设为对照组，治疗4周后对两组的有效率进行比较，同时比较两组治疗前后心绞痛发作频率、硝酸甘油用量情况。 结果 观察组治疗后的总有效率为90.0%，显著高于对照组的70.0%，差异有统计学意义（P0.05）。观察组治疗后心绞痛发作频率显著降低，且显著低于对照组，差异有统计学意义（P0.05）。观察组治疗后硝酸甘油用量显著减少，且显著少于对照组，差异有统计学意义（P0.05）。 结论 氯吡格雷联合瑞舒伐他汀治疗不稳定型心绞痛可以提高疗效，改善临床症状、安全性好，值得??广应用。 　　[关键词] 不稳定型心绞痛；氯吡格雷；瑞舒伐他汀；硝酸甘油 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2015）22-0092-03 　　The clinical effect of clopidogrel combined with rosuvastatin in treatment of unstable angina pectoris 　　GONG Yuxia1 LIUJinwan2 WU Dan2 　　1.Department of Cardiology， the First Ward， the Third Peoples Hospital of Dalian City in Liaoning Province， Dalian 116000， China； 2.Department of Pharmacy， the Third peoples Hospital of Dalian City in Liaoning Province， Dalian 116000， China 　　[Abstract] Objective To evaluate the clinical efficacy of clopidogrel combined with rosuvastatin in treatment of unstable angina pectoris. Methods 100 cases of unstable angina pectoris patients From December 2012 to December 2014， as the research object， 50 cases of patients with unstable angina pectoris by application of clopidogrel combined with rosuvastatin treatment as observation group， 50 cases with unstable angina pectoris by application of clopidogrel treatment as the control group， after 4 weeks of treatment， efficiency， angina attack frequency， nitroglycerin consumption before and after treatment were compared between two groups. Results The total effective rate of the observation group after treatment was 90.0%， significantly higher than the control groups 70.0%， with significant difference（P0.05）. After treatment， angina frequency of observation group significantly decreased， was significantly lower than the control group， the differences was significant（P0.05）. After treatment， the dosage of nitroglycerin of observation group significantly reduced， was significantly less than the cont